Title:
HIV INFECTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/190331
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an HIV infection inhibitor which can act through a mechanism of action that is different from those of conventional anti-HIV drugs, rarely induces drug resistance, and can inhibit HIVs sustainably and effectively.
Provided is a compound represented by general formula (I) or a salt thereof. The compound according to the present invention has a high anti-HIV activity, also has low cytotoxicity, and can achieve a synergistic activity when used in combination with an anti-HIV neutralizing antibody.
Inventors:
TAMAMURA HIROKAZU (JP)
HIROTA YUKI (JP)
IRAHARA YU (JP)
NOMURA WATARU (JP)
NARUMI TETSUO (JP)
MATSUSHITA SHUZO (JP)
YOSHIMURA KAZUHISA (JP)
HARADA SHIGEYOSHI (JP)
HIROTA YUKI (JP)
IRAHARA YU (JP)
NOMURA WATARU (JP)
NARUMI TETSUO (JP)
MATSUSHITA SHUZO (JP)
YOSHIMURA KAZUHISA (JP)
HARADA SHIGEYOSHI (JP)
Application Number:
PCT/JP2016/065395
Publication Date:
December 01, 2016
Filing Date:
May 25, 2016
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
NAT UNIV CORP KUMAMOTO UNIV (JP)
NAT UNIV CORP KUMAMOTO UNIV (JP)
International Classes:
C07D221/20; A61K31/438; A61K39/395; A61P31/18; A61P43/00
Domestic Patent References:
WO2010053583A2 | 2010-05-14 | |||
WO2013090696A1 | 2013-06-20 | |||
WO2015120440A2 | 2015-08-13 | |||
WO2016025681A1 | 2016-02-18 |
Foreign References:
US20140377219A1 | 2014-12-25 |
Other References:
LALONDE, J. M. ET AL.: "Structure-based Design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors", J. MED. CHEM., vol. 55, no. 9, 2012, pages 4382 - 4396, XP055073058
NARUMI, T. ET AL.: "Small molecular CD 4 mimics as HIV entry inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 22, 2011, pages 6735 - 6742, XP028328572
OHASHI, N. ET AL.: "Small-molecule CD 4 mimics containing mono-cyclohexyl moieties as HIV entry inhibitors", CHEMMEDCHEM, vol. 11, no. 8, 19 April 2016 (2016-04-19), pages 940 - 946, XP055332369
NARUMI, T. ET AL.: "Small molecular CD 4 mimics as HIV entry inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 22, 2011, pages 6735 - 6742, XP028328572
OHASHI, N. ET AL.: "Small-molecule CD 4 mimics containing mono-cyclohexyl moieties as HIV entry inhibitors", CHEMMEDCHEM, vol. 11, no. 8, 19 April 2016 (2016-04-19), pages 940 - 946, XP055332369
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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