Title:
HLA-A2 RESTRAINT TUMOR ANTIGEN PEPTIDE ORIGINATING IN SART-1
Document Type and Number:
WIPO Patent Application WO/2000/006595
Kind Code:
A1
Abstract:
An HLA-A2 restraint tumor antigen peptide originating in SART-1 and its derivative having functional characteristics comparable thereto; remedies, preventives or diagnostics for tumor with the use of the tumor antigen peptide, etc.; recombinant DNAs, recombinant peptides and antibodies relating to the tumor antigen peptide and use of the same; antigen presenting cells presenting the tumor antigen peptide and use of the same; and cytotoxic T cells specific to the tumor antigen peptide and use of the same.
Inventors:
ITOH KYOGO (JP)
KOBAYASHI TERUTADA (JP)
KOBAYASHI TERUTADA (JP)
Application Number:
PCT/JP1999/004010
Publication Date:
February 10, 2000
Filing Date:
July 27, 1999
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
ITOH KYOGO (JP)
KOBAYASHI TERUTADA (JP)
ITOH KYOGO (JP)
KOBAYASHI TERUTADA (JP)
International Classes:
C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C07K7/06; A61K38/08; C12N15/12; C07K16/18; C12N5/10; A61K35/14
Domestic Patent References:
| WO1997046676A1 | 1997-12-11 | |||
| WO1999029715A1 | 1999-06-17 |
Other References:
SHICHIJO S. ET AL: "A Gene Encoding Antigenic Peptides of Human Squamous Cell Carcinoma Recognized by Cytotoxic T Lymphocyte", J. EXP. MED.,, vol. 187, no. 3, 2 February 1998 (1998-02-02), pages 277 - 288, XP002922825
NAKAO M. ET AL: "HLA A2601-Restricted CTLs Recognize a Peptide Antigen Expressed on Squamous Cell Carcinoma", CANCER RESEARCH, vol. 55, no. 19, 1 October 1995 (1995-10-01), pages 4248 - 4252, XP002922826
RIVOLTINI L. ET AL: "Induction of Tumor-Reactive CTL from Peripheral Blood and Tumor-Infiltrating Lymphocytes of Melanoma Patients by In Vitro Stimulation with an Immunodominant Peptide of the Human Melanoma Antigen MART-1", THE JOURNAL OF IMMUNOLOGY, vol. 154, no. 5, 1995, pages 2257 - 2265, XP002922827
RAMMENSEE H.G. ET AL: "MHC Ligands and peptide Motifs: First Listing", IMMUNOGENETICS, vol. 41, no. 4, 1995, pages 178 - 228, XP002922828
SUDO T. ET AL: "Differences in MHC Class I Self Peptide Repertoires Among HLA-A2 Subtype", THE JOURNAL OF IMMUNOLOGY, vol. 155, no. 10, 1995, pages 4749 - 4756, XP002922829
KIKUCHI M. ET AL: "Identification of a SART-1-Derived Peptide Capble of Inducing HLA-A24-Restricted and Tumor-Specific Cytotoxic T Lymphocytes", INT. J. CANCER, vol. 81, no. 3, May 1999 (1999-05-01), pages 459 - 466, XP002922830
NAKAO M. ET AL: "HLA A2601-Restricted CTLs Recognize a Peptide Antigen Expressed on Squamous Cell Carcinoma", CANCER RESEARCH, vol. 55, no. 19, 1 October 1995 (1995-10-01), pages 4248 - 4252, XP002922826
RIVOLTINI L. ET AL: "Induction of Tumor-Reactive CTL from Peripheral Blood and Tumor-Infiltrating Lymphocytes of Melanoma Patients by In Vitro Stimulation with an Immunodominant Peptide of the Human Melanoma Antigen MART-1", THE JOURNAL OF IMMUNOLOGY, vol. 154, no. 5, 1995, pages 2257 - 2265, XP002922827
RAMMENSEE H.G. ET AL: "MHC Ligands and peptide Motifs: First Listing", IMMUNOGENETICS, vol. 41, no. 4, 1995, pages 178 - 228, XP002922828
SUDO T. ET AL: "Differences in MHC Class I Self Peptide Repertoires Among HLA-A2 Subtype", THE JOURNAL OF IMMUNOLOGY, vol. 155, no. 10, 1995, pages 4749 - 4756, XP002922829
KIKUCHI M. ET AL: "Identification of a SART-1-Derived Peptide Capble of Inducing HLA-A24-Restricted and Tumor-Specific Cytotoxic T Lymphocytes", INT. J. CANCER, vol. 81, no. 3, May 1999 (1999-05-01), pages 459 - 466, XP002922830
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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