HMGN2 PEPTIDES AND RELATED MELECULES THAT SELECTIVELY HOME TO TUMOR BLOOD VESSELS AND TUMOR CELLS

WIPO Patent Application WO2003087124

A3

The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.

JPH07500723	INDUSTRIAL APPLICABILITY: A method for detecting differentiation and invasiveness in tumor cells of epithelial origin and tumors, and a nucleic acid probe for detection.
WO1999066944	METHODS FOR IDENTIFYING NOVEL MULTIMERIC AGENTS THAT MODULATE RECEPTORS
WO/2003/012127	ASSAY FOR IDENTIFYING INHIBITORS OF HIV RT DIMERIZATION

RUOSLAHTI ERKKI (US)
PORKKA KIMMO (FI)
CHRISTIAN SVEN (US)

PCT/US2003/010240

August 17, 2006

April 02, 2003

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BURNHAM INST (US)
RUOSLAHTI ERKKI (US)
PORKKA KIMMO (FI)
CHRISTIAN SVEN (US)

C07K4/00; A01N37/18; A61K38/00; A61K39/395; A61K47/48; A61K49/00; C07K2/00; C07K5/00; C07K7/00; C07K14/00; C07K14/47; C07K16/00; C07K17/00

US6468758B1

2002-10-22

WALKER R. ET AL.: "The Partial Amino Acid Sequence of a Non-Histone Chromosomal Protein", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 73, no. 1, November 1976 (1976-11-01), pages 72 - 78, XP024845966, DOI: doi:10.1016/0006-291X(76)90498-8
PORKKA ET AL: "A Fragment of the HMGN2 Protein Homes to the Nuclei of Tumor Cells and Tumor Endothelial Cells In Vivo", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 11, May 2002 (2002-05-01), pages 7444 - 7449, XP002904203

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