Title:
HOST CELL OBTAINED BY TRANSFERRING VHL GENE INTO CANCER CELL OR EMBRYONIC STEM CELL AND EXPRESSING
Document Type and Number:
WIPO Patent Application WO/2002/026977
Kind Code:
A1
Abstract:
A host capable of serving as a nerve cell which is constructed by transferring von Hippel-Lindau gene into a cancer cell such as a neuroblastoma cell or an undifferentiated tumor cell originating in the nervous system or an embryonic stem cell and expressing therein. The obtained host is proliferated in vitro and then transplanted into the central nervous system or peripheral nerve. After taking, it is allowed to function as a nerve cell to thereby treat intractable nerve diseases concerning function injury such as Parkinson's disease, amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, brain infarction, spinal cord injury, cerebral contusion, malignant tumor, etc.
Inventors:
KANNO HIROSHI (JP)
Application Number:
PCT/JP2000/006668
Publication Date:
April 04, 2002
Filing Date:
September 27, 2000
Export Citation:
Assignee:
FRETEK CO LTD (JP)
KANNO HIROSHI (JP)
KANNO HIROSHI (JP)
International Classes:
A61K35/12; A61K35/13; A61K35/30; A61K35/48; A61K35/545; A61P9/10; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P35/00; C12N5/079; C12N15/113; C12N15/12; (IPC1-7): C12N15/12; C12N5/08; C12N5/10; A61K35/12; A61K35/30; A61K48/00; A61K31/711; A61P25/16; A61P21/04; A61P25/14; A61P25/28; A61P9/10; A61P25/00; A61P35/00
Other References:
KANNO H. ET AL.: "Role of the von hippel-lindau tumor suppressor protein during neutonal differentiation", CANCER RESEARCH, vol. 60, June 2000 (2000-06-01), pages 2820 - 2824, XP002933172
LATIF F. ET AL.: "Identification of the von hippel-lindau disease tumor suppressor gene", SCIENCE, vol. 260, May 1993 (1993-05-01), pages 1317 - 1320, XP002933173
GNARRA J.R. ET AL.: "Molecular cloning of the von hippel-lindau tumor suppressor gene and its role in renal carcinoma", BIOCHEMICA ET BIOPHYSICA ACTA, vol. 1242, no. 3, March 1996 (1996-03-01), pages 201 - 210, XP002933174
WATKINS D. ET AL.: "Genetics, prognosis and therapy of central nervous system tumors", CANCER DETECTION AND PREVENTION, vol. 18, no. 2, 2000, pages 139 - 144, XP002933175
MCDONALD J.W. ET AL.: "Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord", NATURE MEDICINE, vol. 5, no. 12, December 1999 (1999-12-01), pages 1410 - 1412, XP002933176
LATIF F. ET AL.: "Identification of the von hippel-lindau disease tumor suppressor gene", SCIENCE, vol. 260, May 1993 (1993-05-01), pages 1317 - 1320, XP002933173
GNARRA J.R. ET AL.: "Molecular cloning of the von hippel-lindau tumor suppressor gene and its role in renal carcinoma", BIOCHEMICA ET BIOPHYSICA ACTA, vol. 1242, no. 3, March 1996 (1996-03-01), pages 201 - 210, XP002933174
WATKINS D. ET AL.: "Genetics, prognosis and therapy of central nervous system tumors", CANCER DETECTION AND PREVENTION, vol. 18, no. 2, 2000, pages 139 - 144, XP002933175
MCDONALD J.W. ET AL.: "Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord", NATURE MEDICINE, vol. 5, no. 12, December 1999 (1999-12-01), pages 1410 - 1412, XP002933176
Attorney, Agent or Firm:
Hiraki, Yusuke (Toranomon 1-chome Minato-ku, Tokyo, JP)
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