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Patent Searching and Data


Title:
HOST CELL FOR PRODUCING RECOMBINANT PROTEIN
Document Type and Number:
WIPO Patent Application WO/2007/034809
Kind Code:
A1
Abstract:
It is intended to provide a host cell which can be proliferated in a serum-free medium, synthesize and secret a desired protein in a large amount and produce a glycoprotein having a sugar chain structure. Namely, an established cell line having been established from distal tubular epithelial cells originating in a mammal is provided.

Inventors:
TAIRA HIDEHARU (JP)
YAMASHITA TETSURO (JP)
MIYAZAKI MASAO (JP)
Application Number:
PCT/JP2006/318587
Publication Date:
March 29, 2007
Filing Date:
September 20, 2006
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
TAIRA HIDEHARU (JP)
YAMASHITA TETSURO (JP)
MIYAZAKI MASAO (JP)
International Classes:
C12N15/00; C07K2/00; C12N5/071; C12N5/10; C12N15/09; C12P21/00
Other References:
HERZLINGER D.A. ET AL.: "The MDCK epithelial cell line expresses a cell surface antige of the kidney distal tubules", J. CELL BIOL., vol. 93, May 1982 (1982-05-01), pages 269 - 277, XP003010658
TAUB M. ET AL.: "Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium", vol. 76, no. 7, July 1979 (1979-07-01), pages 3338 - 3342, XP003010659
HE Z. ET AL.: "Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vitro", CANCER RES., vol. 59, 1 July 1999 (1999-07-01), pages 3222 - 3229, XP002963205
HEODRICH H.-G. ET AL.: "Homogeneous cell populations from rabbit kidney cortex, Proximal, distal tubule, and renin-active cell isolated by free-flow electrophoresis", J. CELL BIOL., vol. 74, 1977, pages 780 - 788, XP003010660
TAUB M. ET AL.: "Clonal analysis of immortalized renalproximal tubule cells: Na+/Glucose cotransport system levels are maintained despite a decline in transport function", EXP. CELL RES., vol. 281, 2002, pages 205 - 212, XP003010661
HERZLINGER ET AL., J. CELL. BIOL., vol. 93, 1982, pages 269 - 277
TAUB ET AL., PNAS, vol. 76, no. 7, 1979, pages 3338 - 3342
HE; BATEMAN, CANCER RESEARCH, vol. 59, 1999, pages 3222 - 3229
GONZALEZ ET AL., PNAS, vol. 84, 1987, pages 3738 - 3742
"Soshiki Baiyo no Gijyutsu", ASAKURA SHOTEN, pages: 141 - 145
"Tissue Culture Techniques", ASAKURA SHOTEN, pages: 141 - 145
Attorney, Agent or Firm:
SIKs & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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