Title:
HOST CELLS AND METHODS FOR PRODUCTION OF ISOBUTANOL
Document Type and Number:
WIPO Patent Application WO/2012/129555
Kind Code:
A3
Abstract:
Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
Inventors:
ANTHONY LARRY CAMERON (US)
GIBSON KATHARINE J (US)
HE HONGXIAN (US)
HUANG LISA L (US)
O'KEEFE DANIEL P (US)
KRUCKEBERG ARTHUR LEO (US)
LI YOUGEN (US)
MAGGIO-HALL LORI ANN (US)
MCELVAIN JESSICA (US)
NELSON MARK J (US)
PATNAIK RANJAN (US)
ROTHMAN STEVEN CARY (US)
GIBSON KATHARINE J (US)
HE HONGXIAN (US)
HUANG LISA L (US)
O'KEEFE DANIEL P (US)
KRUCKEBERG ARTHUR LEO (US)
LI YOUGEN (US)
MAGGIO-HALL LORI ANN (US)
MCELVAIN JESSICA (US)
NELSON MARK J (US)
PATNAIK RANJAN (US)
ROTHMAN STEVEN CARY (US)
Application Number:
PCT/US2012/030479
Publication Date:
February 28, 2013
Filing Date:
March 23, 2012
Export Citation:
Assignee:
BUTAMAX TM ADVANCED BIOFUELS (US)
ANTHONY LARRY CAMERON (US)
GIBSON KATHARINE J (US)
HE HONGXIAN (US)
HUANG LISA L (US)
O'KEEFE DANIEL P (US)
KRUCKEBERG ARTHUR LEO (US)
LI YOUGEN (US)
MAGGIO-HALL LORI ANN (US)
MCELVAIN JESSICA (US)
NELSON MARK J (US)
PATNAIK RANJAN (US)
ROTHMAN STEVEN CARY (US)
ANTHONY LARRY CAMERON (US)
GIBSON KATHARINE J (US)
HE HONGXIAN (US)
HUANG LISA L (US)
O'KEEFE DANIEL P (US)
KRUCKEBERG ARTHUR LEO (US)
LI YOUGEN (US)
MAGGIO-HALL LORI ANN (US)
MCELVAIN JESSICA (US)
NELSON MARK J (US)
PATNAIK RANJAN (US)
ROTHMAN STEVEN CARY (US)
International Classes:
C12N15/61; C12N15/53; C12N15/63; C12P7/16; C12P7/52
Domestic Patent References:
| WO2010051527A2 | 2010-05-06 | |||
| WO2010062597A1 | 2010-06-03 | |||
| WO2011019894A1 | 2011-02-17 | |||
| WO2008130995A2 | 2008-10-30 |
Other References:
DATABASE GENBANK [online] 12 December 2004 (2004-12-12), "ketol-acid reductoisomerase [Zymomonas mobilis subsp. mobilis ZM4]", XP003030166, Database accession no. YP_162876
DATABASE GENBANK [online] 12 January 2011 (2011-01-12), "ketol-acid reductoisomerase [Anaerostipes sp. 3_2_56FAA]", XP003030167, Database accession no. ZP_07930881
DATABASE GENBANK [online] 12 January 2011 (2011-01-12), "ketol-acid reductoisomerase [Anaerostipes sp. 3_2_56FAA]", XP003030167, Database accession no. ZP_07930881
Attorney, Agent or Firm:
LHULIER, Christine, M. (Legal Patent Records Center4417 Lancaster Pik, Wilmington Delaware, US)
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