Title:
HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS
Document Type and Number:
WIPO Patent Application WO/2017/014296
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a use for a UCA1 gene, which is a host regulation factor that enhances proliferation and propagation of the vaccinia virus, so that cancer virotherapy using the vaccinia virus can be effectively carried out. The present invention is: a method for making a predictive evaluation of the efficacy of a cancer treatment using the vaccinia virus, by measuring the expression of the UCA1 gene in cancer cells of a cancer patient, and if the UCA1 gene is expressed, predicting that a cancer treatment using the vaccinia virus will be effective in the patient; and a vaccinia virus introduced in a manner enabling UCA1 gene expression.
Inventors:
NAKAMURA TAKAFUMI (JP)
HORITA KOUSUKE (JP)
KUROSAKI HAJIME (JP)
NAKATAKE MOTOMU (JP)
HORITA KOUSUKE (JP)
KUROSAKI HAJIME (JP)
NAKATAKE MOTOMU (JP)
Application Number:
PCT/JP2016/071538
Publication Date:
January 26, 2017
Filing Date:
July 22, 2016
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
International Classes:
C12Q1/68; A61K35/76; A61K35/768; A61P35/00; C12N7/01; C12N7/04; C12N15/09; G01N33/53
Domestic Patent References:
| WO2015076422A1 | 2015-05-28 | |||
| WO2015027163A1 | 2015-02-26 | |||
| WO2011125469A1 | 2011-10-13 |
Other References:
LIU, Y. ET AL.: "Long Non Coding RNA-UCA1 Contributes to Cardiomyocyte Apoptosis by Suppression of p27 Expression", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 35, 2015, pages 1986 - 1998, XP055348485, ISSN: 1015-8987
BEARD, P. M. ET AL.: "A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference", PLOS ONE, vol. 9, no. 6, 2014, pages 1 - 10, XP055348486, ISSN: 1932-6203
LIU, S-P. ET AL.: "Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials", CANCER BIOLOGY & MEDICINE, vol. 10, 2013, pages 138 - 141, XP055348487, ISSN: 2095-3941
BEARD, P. M. ET AL.: "A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference", PLOS ONE, vol. 9, no. 6, 2014, pages 1 - 10, XP055348486, ISSN: 1932-6203
LIU, S-P. ET AL.: "Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials", CANCER BIOLOGY & MEDICINE, vol. 10, 2013, pages 138 - 141, XP055348487, ISSN: 2095-3941
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
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