Title:
HPV CD8+ T-CELL EPITOPES
Document Type and Number:
WIPO Patent Application WO2005026192
Kind Code:
A3
Abstract:
The present invention provides means to identify functional CD8+ T- cell epitopes in any protein of interest. The present invention further provides CD8+ T- cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines. In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high- risk HPV strains. In particular, the present invention provides means to identify CD8+ T- cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high- risk HPV types that prevent the development of begnin and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
Inventors:
HARDING FIONA A (US)
MUCHA JEANETTE MARIE (US)
MUCHA JEANETTE MARIE (US)
Application Number:
PCT/US2004/027271
Publication Date:
May 12, 2005
Filing Date:
August 23, 2004
Export Citation:
Assignee:
INNOGENETICS NV (BE)
HARDING FIONA A (US)
MUCHA JEANETTE MARIE (US)
HARDING FIONA A (US)
MUCHA JEANETTE MARIE (US)
International Classes:
A61K38/00; C07H21/04; C07K14/01; C07K14/74; C12N7/00; C12P21/04; C12Q1/68; G01N33/50; G01N33/53; G01N33/567; G01N33/68; A61K; C07K; (IPC1-7): A61K38/00
Foreign References:
| US4777239A | 1988-10-11 | |||
| US5415995A | 1995-05-16 | |||
| US5180806A | 1993-01-19 |
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