Title:
HTLV-1 NUCLEIC ACID LIPID PARTICLE VACCINE
Document Type and Number:
WIPO Patent Application WO/2022/244801
Kind Code:
A1
Abstract:
Provided is a vaccine for the treatment and/or prevention of infection by human T-cell leukemia virus type 1 (HTLV-1). A lipid particle of the present invention has encapsulated therein a nucleic acid that enables expression of the Tax antigen or the gp46 antigen of HTLV-1. The particle includes a lipid including a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof. In the formula: R1 and R2 independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group optionally having one or more C2-C4 alkanoyloxy groups or represents a C10-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; and p represents 3 or 4.
Inventors:
ISHII KEN (JP)
FUKUSHIMA TAKUYA (JP)
TANAKA YUETSU (JP)
TAKESHITA FUMIHIKO (JP)
KOIZUMI MAKOTO (JP)
NIWA TAKAKO (JP)
NOGUSA SHOKO (JP)
JONAI NAO (JP)
ONODERA YOSHIKUNI (JP)
FUKUSHIMA TAKUYA (JP)
TANAKA YUETSU (JP)
TAKESHITA FUMIHIKO (JP)
KOIZUMI MAKOTO (JP)
NIWA TAKAKO (JP)
NOGUSA SHOKO (JP)
JONAI NAO (JP)
ONODERA YOSHIKUNI (JP)
Application Number:
PCT/JP2022/020646
Publication Date:
November 24, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
UNIV OF THE RYUKYUS (JP)
DAIICHI SANKYO CO LTD (JP)
UNIV OF THE RYUKYUS (JP)
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K39/21; A61K9/127; A61K31/7115; A61K38/16; A61K47/10; A61K47/18; A61K47/24; A61K47/28; A61P31/14; C12N15/88
Domestic Patent References:
| WO2015005253A1 | 2015-01-15 | |||
| WO2015164674A1 | 2015-10-29 | |||
| WO2015005253A1 | 2015-01-15 |
Foreign References:
| JP2010508014A | 2010-03-18 | |||
| JP2021084942A | 2021-06-03 |
Other References:
OHASHI T, ET AL.: "Prevention of adult T-cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T-cell leukemia virus type I Tax-coding DNA vaccine.", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 20, 1 October 2000 (2000-10-01), US , pages 9610 - 9616, XP002467099, ISSN: 0022-538X, DOI: 10.1128/JVI.74.20.9610-9616.2000
OHASHI, TAKASHI ET AL.: "1-C-131-P/O Analysis of cytotoxicity for HTLV-I infected cells of CTL lines induced from rats vaccinated with Tax-expressing DNA", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, NIHON MEN'EKI GAKKAI // JAPANESE SOCIETY FOR IMMUNOLOGY (JSI), JP, vol. 30, 1 January 2000 (2000-01-01) - 16 November 2000 (2000-11-16), JP , pages 57, XP009541316, ISSN: 0919-1984
"2003 collection of research reports on a particular field (cancer-specific) related to cancer research", 1 January 2004, INSTITUTE OF MOLECULAR AND CELLULAR BIOLOGY, UNIVERSITY OF TOKYO , JP, article TAKASHI OHASHI: "Development of immunotherapy for human adult T-cell leukemia using rat models", pages: 129 - 131, XP009542710
KABIRI MONA, SANKIAN MOJTABA, HOSSEINPOUR MITRA, TAFAGHODI MOHSEN: "The novel immunogenic chimeric peptide vaccine to elicit potent cellular and mucosal immune responses against HTLV-1", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 549, no. 1-2, 1 October 2018 (2018-10-01), NL , pages 404 - 414, XP093006331, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.07.069
HASEGAWA, HIDEKI ET AL.: "Analysis of anti-HTLV antibody response in breast milk of vaccinated mother mice", SCIENTIFIC RESEARCH GRANTS OF THE MINISTRY OF HEALTH, LABOR, AND WELFARE OF JAPAN. EMERGING AND RE-EMERGING INFECTIOUS DISEASE RESEARCH PROJECT SUCH AS NEW STRAINS OF INFLUENZA. RESEARCH ON THE DEVELOPMENT OF A PROPHYLACTIC VACCINE FOR HTLV-A INFECTI, 1 January 2013 (2013-01-01), pages 11 - 15, XP009542646
FRONT MICROBIOL., vol. 3, 2012, pages 406
BLOOD, vol. 119, no. 10, 2012, pages 2409 - 2416
CANCER RESEARCH, vol. 70, no. 15, 2010, pages 6181 - 6192
LANCET INFECT DIS, vol. 7, 2007, pages 266 - 281
VIRUSES, vol. 3, no. 6, 2011, pages 714 - 749
GENE DEV., vol. 4, 1990, pages 1875
J. BIOCHEM., vol. 150, no. 6, 2011, pages 679 - 686
J. BIOL CHEM., vol. 281, no. 19, 2006, pages 13075 - 13082
VIRUSES, vol. 8, no. 2, 2016, pages 41
SCIENCE, vol. 371, 2021, pages 1152
J. BIOL. CHEM., vol. 267, 1992, pages 16396
J. BIOL. CHEM., vol. 266, 1991, pages 12127
SAMBROOK, J. ET AL.: "Molecular Cloning a Laboratory Manual", 1989
RASHTCHIAN, A., CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1995, pages 30 - 36
GIBSON D. G. ET AL., SCIENCE, vol. 319, no. 5867, 2008, pages 1215 - 1220
KORMANN, M., NATURE BIOTECHNOLOGY, vol. 29, 2011, pages 154 - 157
"Uniprot", Database accession no. P03409
OHASHI, TAKASHI ET AL.: "1-C-131-P/O Analysis of cytotoxicity for HTLV-I infected cells of CTL lines induced from rats vaccinated with Tax-expressing DNA", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, NIHON MEN'EKI GAKKAI // JAPANESE SOCIETY FOR IMMUNOLOGY (JSI), JP, vol. 30, 1 January 2000 (2000-01-01) - 16 November 2000 (2000-11-16), JP , pages 57, XP009541316, ISSN: 0919-1984
"2003 collection of research reports on a particular field (cancer-specific) related to cancer research", 1 January 2004, INSTITUTE OF MOLECULAR AND CELLULAR BIOLOGY, UNIVERSITY OF TOKYO , JP, article TAKASHI OHASHI: "Development of immunotherapy for human adult T-cell leukemia using rat models", pages: 129 - 131, XP009542710
KABIRI MONA, SANKIAN MOJTABA, HOSSEINPOUR MITRA, TAFAGHODI MOHSEN: "The novel immunogenic chimeric peptide vaccine to elicit potent cellular and mucosal immune responses against HTLV-1", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 549, no. 1-2, 1 October 2018 (2018-10-01), NL , pages 404 - 414, XP093006331, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.07.069
HASEGAWA, HIDEKI ET AL.: "Analysis of anti-HTLV antibody response in breast milk of vaccinated mother mice", SCIENTIFIC RESEARCH GRANTS OF THE MINISTRY OF HEALTH, LABOR, AND WELFARE OF JAPAN. EMERGING AND RE-EMERGING INFECTIOUS DISEASE RESEARCH PROJECT SUCH AS NEW STRAINS OF INFLUENZA. RESEARCH ON THE DEVELOPMENT OF A PROPHYLACTIC VACCINE FOR HTLV-A INFECTI, 1 January 2013 (2013-01-01), pages 11 - 15, XP009542646
FRONT MICROBIOL., vol. 3, 2012, pages 406
BLOOD, vol. 119, no. 10, 2012, pages 2409 - 2416
CANCER RESEARCH, vol. 70, no. 15, 2010, pages 6181 - 6192
LANCET INFECT DIS, vol. 7, 2007, pages 266 - 281
VIRUSES, vol. 3, no. 6, 2011, pages 714 - 749
GENE DEV., vol. 4, 1990, pages 1875
J. BIOCHEM., vol. 150, no. 6, 2011, pages 679 - 686
J. BIOL CHEM., vol. 281, no. 19, 2006, pages 13075 - 13082
VIRUSES, vol. 8, no. 2, 2016, pages 41
SCIENCE, vol. 371, 2021, pages 1152
J. BIOL. CHEM., vol. 267, 1992, pages 16396
J. BIOL. CHEM., vol. 266, 1991, pages 12127
SAMBROOK, J. ET AL.: "Molecular Cloning a Laboratory Manual", 1989
RASHTCHIAN, A., CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1995, pages 30 - 36
GIBSON D. G. ET AL., SCIENCE, vol. 319, no. 5867, 2008, pages 1215 - 1220
KORMANN, M., NATURE BIOTECHNOLOGY, vol. 29, 2011, pages 154 - 157
"Uniprot", Database accession no. P03409
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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