Title:
HUMAN ADULT STEM CELL FOR EXPRESSING ANTI-MDM2, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/090297
Kind Code:
A2
Abstract:
The present invention relates to a human neural stem cell comprising nucleic acids encoding anti-MDM2, and to a pharmaceutical composition for treating cancer comprising same. The human neural stem cell comprising nucleic acids encoding anti-MDM2 according to the present invention does not induce cytotoxicity, and secretes anti-MDM2 in vivo to induce the apoptosis of abnormal cells, and thus can be used effectively in the prevention or treatment of diseases related to the hyperproliferation of cells such as cancer or the like.
Inventors:
PARK KOOK IN (KR)
KIM IL SUN (KR)
KIM IL SUN (KR)
Application Number:
PCT/KR2011/000329
Publication Date:
July 28, 2011
Filing Date:
January 17, 2011
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
PARK KOOK IN (KR)
KIM IL SUN (KR)
PARK KOOK IN (KR)
KIM IL SUN (KR)
International Classes:
C12N5/074; A61P35/00; C12N15/09; C12N15/86
Domestic Patent References:
| WO1996002642A1 | 1996-02-01 |
Other References:
CHENE ET AL.: 'Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface' MOLECULAR CANCER RESEARCH vol. 2, 2004, pages 20 - 28
MENG ET AL.: 'Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis Type VII Mouse' JOURNAL OF NEUROSCIENCE RESEARCH vol. 74, 2003, pages 266 - 277
MENG ET AL.: 'Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis Type VII Mouse' JOURNAL OF NEUROSCIENCE RESEARCH vol. 74, 2003, pages 266 - 277
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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Claims:
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