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Title:
HUMAN AIRWAY STEM CELLS IN LUNG EPITHELIAL ENGINEERING
Document Type and Number:
WIPO Patent Application WO/2017/200762
Kind Code:
A3
Abstract:
Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.

Inventors:
GILPIN, Sarah E. (36 College Avenue, Apt. 45Somerville, Massachusetts, 02144, US)
OTT, Harald C. (356 Grapevine Road, Wenham, Massachusetts, 01984, US)
Application Number:
US2017/031076
Publication Date:
February 08, 2018
Filing Date:
May 04, 2017
Export Citation:
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Assignee:
THE GENERAL HOSPITAL CORPORATION (55 Fruit Street, Boston, Massachusetts, 02114, US)
GILPIN, Sarah E. (36 College Avenue, Apt. 45Somerville, Massachusetts, 02144, US)
International Classes:
A61K35/12; A61K35/42; C12M3/00; C12N5/00; C12N5/071
Domestic Patent References:
WO2015138999A12015-09-17
Foreign References:
US20120141439A12012-06-07
US20150289501A12015-10-15
US20150182560A12015-07-02
Other References:
GILPIN ET AL.: "Using nature's platform to engineer bio-artificial lungs", ANN AM THORAC SOC, vol. 12, no. 1, March 2015 (2015-03-01), pages S45 - S49, XP055459558
GILPIN ET AL.: "Regenerative potential of human airway stem cells in lung epithelial engineering", BIOMATERIALS, vol. 108, 4 September 2016 (2016-09-04), pages 111 - 119, XP029741561
OTT ET AL.: "Regeneration and orthotopic transplantation of a bioartificial lung", NAT MED., vol. 16, 13 July 2010 (2010-07-13), pages 927 - 933, XP055459559
SONG ET AL.: "Enhanced in vivo function of bioartificial lungs in rats", ANN THORAC SURG, vol. 92, no. 3, September 2011 (2011-09-01), pages 998 - 1005, XP028279536
VAUGHAN ET AL.: "Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury", NATURE, vol. 517, 24 December 2014 (2014-12-24), pages 621 - 625, XP055459561
Attorney, Agent or Firm:
DEYOUNG, Janice Kugler et al. (Fish & Richardson P.C, P.O. Box 1022Minneapolis, Minnesota, 55440-1022, US)
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