Title:
HUMAN AKT-3
Document Type and Number:
WIPO Patent Application WO2000037613
Kind Code:
A3
Abstract:
There is disclosed a nucleic acid molecule encoding human Akt-3 protein or a functional equivalent or bioprecursor thereof comprising the amino acid sequence illustrated in Sequence ID No. 3. The human Akt-3 protein itself also forms part of the invention. The nucleic acid molecule and the human Akt-3 protein may themselves be used as medicaments, or in the preparation of medicaments for treating cancer, in their own right or in the form of a pharmaceutically acceptable carrier, diluent or excipient thereof. Further disclosed are methods of identifying agents which influence the activity of a human Akt-3 protein.
Inventors:
MASURE STEFAN LEO JOZEF (BE)
RICHARDSON ALAN (BE)
RICHARDSON ALAN (BE)
Application Number:
PCT/GB1999/004311
Publication Date:
November 16, 2000
Filing Date:
December 17, 1999
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
MASURE STEFAN LEO JOZEF (BE)
RICHARDSON ALAN (BE)
MASURE STEFAN LEO JOZEF (BE)
RICHARDSON ALAN (BE)
International Classes:
A61K31/713; A61K38/45; A61K38/53; A61K39/395; A61K48/00; A61P35/00; A61P43/00; C07K16/40; C12N1/15; G01N33/50; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N9/12; C12N15/09; C12N15/10; C12N15/54; C12N15/70; C12N15/85; C12P21/08; C12Q1/02; C12Q1/48; G01N33/15; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): C12N9/12; C12N15/10; C12N15/70; C12N15/85; C12N5/10; C07K16/40; C12Q1/48; A61K38/45; A61K39/395
Domestic Patent References:
| WO1997018303A1 | 1997-05-22 |
Other References:
MASURE, S. ET AL.: "Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 265, 1999, pages 353 - 360, XP000917167
BRODBECK, D. ET AL.: "A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 14, 2 April 1999 (1999-04-02), pages 9133 - 9136, XP000919262
WALKER, K.S. ET AL.: "Activation of protein kinase B ß and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha", THE BIOCHEMICAL JOURNAL, vol. 331, no. 1, 1 April 1998 (1998-04-01), pages 299 - 308, XP000917147
KONISHI, H. ET AL.: "Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and ß/gamma subunits of G proteins", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 216, no. 2, 13 November 1995 (1995-11-13), pages 526 - 534, XP002030406
ALTOMARE, D.A. ET AL.: "Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene", ONCOGENE, vol. 11, no. 6, 21 September 1995 (1995-09-21), pages 1055 - 1060, XP000917027
BRODBECK, D. ET AL.: "A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 14, 2 April 1999 (1999-04-02), pages 9133 - 9136, XP000919262
WALKER, K.S. ET AL.: "Activation of protein kinase B ß and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha", THE BIOCHEMICAL JOURNAL, vol. 331, no. 1, 1 April 1998 (1998-04-01), pages 299 - 308, XP000917147
KONISHI, H. ET AL.: "Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and ß/gamma subunits of G proteins", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 216, no. 2, 13 November 1995 (1995-11-13), pages 526 - 534, XP002030406
ALTOMARE, D.A. ET AL.: "Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene", ONCOGENE, vol. 11, no. 6, 21 September 1995 (1995-09-21), pages 1055 - 1060, XP000917027
Download PDF:
Previous Patent: SOMATIC CELLS WITH ABLATED Prp GENE AND METHODS OF USE
Next Patent: VARIANTS OF EGIII-LIKE CELLULASE AND COMPOSITIONS THEREOF
Next Patent: VARIANTS OF EGIII-LIKE CELLULASE AND COMPOSITIONS THEREOF