Title:
HUMAN ANTIBODIES SPECIFIC FOR INTERLEUKIN 15 (IL-15)
Document Type and Number:
WIPO Patent Application WO2003017935
Kind Code:
A3
Abstract:
Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Inventors:
VAN DE WINKEL JAN G J (NL)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE (SE)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE (SE)
Application Number:
PCT/US2002/026769
Publication Date:
August 14, 2003
Filing Date:
August 23, 2002
Export Citation:
Assignee:
GENMAB INC (US)
VAN DE WINKEL JAN G J (NL)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE (SE)
VAN DE WINKEL JAN G J (NL)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE (SE)
International Classes:
A61K39/395; A61K45/00; A61P1/04; A61P17/06; A61P19/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/06; C07K16/24; A01K67/027; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/18; C12N15/09; C12N15/12; C12P21/08; G01N33/53; G01N33/543; (IPC1-7): C12N5/10; C12N5/12; C12N5/16; C12N5/18; C12N15/12; C12N15/63; C12N15/64; C07K14/47; C07K16/24; A61K39/395; A61K39/44
Foreign References:
| US5795966A | 1998-08-18 | |||
| US5591630A | 1997-01-07 |
Other References:
See also references of EP 1425389A4
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