HUMAN ANTIBODIES SPECIFIC FOR INTERLEUKIN 15 (IL-15)

Title:

HUMAN ANTIBODIES SPECIFIC FOR INTERLEUKIN 15 (IL-15)

Document Type and Number:

WIPO Patent Application WO2004076620

Kind Code:

A9

Abstract:

Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

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Inventors:

VAN DE WINKEL JAN G J (NL)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE D M SC (SE)
PETERSEN JOERGEN (DK)

Application Number:

PCT/IB2004/000484

Publication Date:

October 21, 2004

Filing Date:

February 25, 2004

Export Citation:

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Assignee:

GENMAB AS (DK)
VAN DE WINKEL JAN G J (NL)
VAN DIJK MARCUS ANTONIUS (NL)
SCHUURMAN JANINE (NL)
GERRITSEN ARNOUT F (NL)
BAADSGAARD OLE D M SC (SE)
PETERSEN JOERGEN (DK)

International Classes:

A61P17/06; C07K16/24; C12N5/18; C12N15/12; (IPC1-7): C12N/

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