Title:
HUMAN APOBEC3A DEAMINASE-BASED BASE EDITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/020193
Kind Code:
A1
Abstract:
Provided are a human APOBEC3A deaminase-based base editor and a use thereof. The editor can mediate efficient C-to-T nucleotide substitution.
Inventors:
GAO CAIXIA (CN)
ZONG YUAN (CN)
ZONG YUAN (CN)
Application Number:
PCT/CN2019/097398
Publication Date:
January 30, 2020
Filing Date:
July 24, 2019
Export Citation:
Assignee:
INST GENETICS & DEVELOPMENTAL BIOLOGY CAS (CN)
International Classes:
C12N15/62; A01H1/02; C07K19/00; C12N9/22
Domestic Patent References:
| WO2017070632A2 | 2017-04-27 |
Foreign References:
| CN108070611A | 2018-05-25 |
Other References:
ST MARTIN, A.: "A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells", NUCLEIC ACIDS RESEARCH, vol. 46, no. 14, 9 May 2018 (2018-05-09), pages e84, XP055682169, ISSN: 0305-1048
LIU, JIAHUI ET AL: "Research Progress of Base Editing System", WORLD SCI-TECH R&D, vol. 39, no. 6, 15 September 2017 (2017-09-15), pages 457 - 461, ISSN: 1006-6055
LIU, JIAHUI ET AL: "Research Progress of Base Editing System", WORLD SCI-TECH R&D, vol. 39, no. 6, 15 September 2017 (2017-09-15), pages 457 - 461, ISSN: 1006-6055
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD (CN)
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