Title:
HUMAN COAGULATION FACTOR IX (FIX) FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/032786
Kind Code:
A1
Abstract:
A hyperglycosylated recombinant human coagulation factor IX (FIX) fusion protein, a preparation method therefor, and use thereof. The fusion protein sequentially comprises, from N- to C-terminus, a human FIX, a flexible peptide linker, at least one human chorionic gonadotropin β subunit carboxy-terminal peptide rigid unit, and a half-life extending moiety. The fusion protein has a biological activity similar to that of the recombinant FIX, an extended in vivo activity half-life, and reduced immunogenicity, so as to improve pharmacokinetics and pharmacodynamics.
Inventors:
GAO YONGJUAN (CN)
CHEN SI (CN)
LI ZIRUI (CN)
TU XIAOPING (CN)
SUN BILL NAI CHAU (CN)
LI QIANG (CN)
CHEN SI (CN)
LI ZIRUI (CN)
TU XIAOPING (CN)
SUN BILL NAI CHAU (CN)
LI QIANG (CN)
Application Number:
PCT/CN2017/079872
Publication Date:
February 22, 2018
Filing Date:
April 10, 2017
Export Citation:
Assignee:
AMPSOURCE BIOPHARMA INC (CN)
PHARMAB INC (CN)
PHARMAB INC (CN)
International Classes:
C07K19/00; A61K38/36; A61P7/04; C12N5/10; C12N15/62; C12N15/63; C12N15/85
Foreign References:
| CN106317226A | 2017-01-11 | |||
| CN106256835A | 2016-12-28 | |||
| CN106279436A | 2017-01-04 | |||
| CN106279437A | 2017-01-04 | |||
| CN106117370A | 2016-11-16 | |||
| CN103140237A | 2013-06-05 | |||
| CN104693270A | 2015-06-10 | |||
| CN104114183A | 2014-10-22 | |||
| CN103539860A | 2014-01-29 | |||
| CN102639144A | 2012-08-15 |
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