Title:
HUMAN COMMON MONOCYTE PROGENITORS CAPABLE OF DIFFERENTIATING EXCLUSIVELY INTO MONOCYTIC CELLS AND METHOD FOR ISOLATING SAME
Document Type and Number:
WIPO Patent Application WO/2017/179718
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide isolated human common monocyte progenitors which do not differentiate into any cells other than monocytic cells and which have proliferative ability. The present invention relates to: the acquisition of human common monocyte progenitors with strict monocytic differentiation potential by isolating Lin-CD34+CD38+CD10-CD123int/-CD45RA+CD135+CLEC12AhiCD64hi cells from an umbilical cord blood sample or a bone marrow sample; a therapeutic method targeting the human common monocyte progenitors capable of differentiating exclusively into monocytic cells; and a medicinal composition comprising a substance acting specifically on the human common monocyte progenitors capable of differentiating exclusively into monocytic cells.
Inventors:
OHTEKI TOSHIAKI (JP)
KAWAMURA SHUNSUKE (JP)
ONAI NOBUYUKI (JP)
KAWAMURA SHUNSUKE (JP)
ONAI NOBUYUKI (JP)
Application Number:
PCT/JP2017/015356
Publication Date:
October 19, 2017
Filing Date:
April 14, 2017
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
KYOWA HAKKO KIRIN CO LTD (JP)
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C12N5/0786; A01K67/027; A61K39/395; A61K45/00; A61P1/04; A61P3/00; A61P9/10; A61P19/00; A61P35/00; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; A61K35/15; A61K35/51
Domestic Patent References:
| WO2006002438A2 | 2006-01-05 |
Other References:
SHUNSUKE KAWAMURA: "Identification of Common Monocyte Progenitors, Pre-monocytes, and Granulocyte Progenitors in Human Umbilical Cord Blood", EXPERIMENTAL HEMATOLOGY, vol. 43, September 2015 (2015-09-01), pages S72, XP055433247
TAKAHIRO SHIMA: "Identification of Human Monocyte Lineage Proganitors Lacking Granulocyte Potential: Revision of Phenotypic Definition of Human GMP", BLOOD, vol. 116, 2010, XP055433249
ANDREW S.J. MARSHALL: "Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 15, 2004, pages 14792 - 14802, XP002305616
YEN K LIEU: "Impaired Adult Myeloid Progenitor CMP and GMP Cell Function in Conditional c-myb- knockout Mice", CELL CYCLE, vol. 11, no. 18, 2012, pages 3504 - 3512, XP055433254
TAKAHIRO SHIMA: "Identification of Human Monocyte Lineage Proganitors Lacking Granulocyte Potential: Revision of Phenotypic Definition of Human GMP", BLOOD, vol. 116, 2010, XP055433249
ANDREW S.J. MARSHALL: "Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 15, 2004, pages 14792 - 14802, XP002305616
YEN K LIEU: "Impaired Adult Myeloid Progenitor CMP and GMP Cell Function in Conditional c-myb- knockout Mice", CELL CYCLE, vol. 11, no. 18, 2012, pages 3504 - 3512, XP055433254
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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