Title:
HUMAN EROSIVE RHEUMATOID ARTHRITIS MODEL NON-HUMAN MAMMAL
Document Type and Number:
WIPO Patent Application WO/2011/049239
Kind Code:
A1
Abstract:
Disclosed is a model non-human mammal which develops human erosive rheumatoid arthritis. Specifically disclosed is a human erosive rheumatoid arthritis model non-human mammal, which is produced by infecting a non-human mammal having a human immune system an Epstein-Barr virus and is characterized by developing human erosive rheumatoid arthritis.
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Inventors:
TAKEI MASAMI (JP)
SAWADA SHIGEMASA (JP)
SAWADA SHIGEMASA (JP)
Application Number:
PCT/JP2010/069117
Publication Date:
April 28, 2011
Filing Date:
October 21, 2010
Export Citation:
Assignee:
UNIV NIHON (JP)
TAKEI MASAMI (JP)
SAWADA SHIGEMASA (JP)
TAKEI MASAMI (JP)
SAWADA SHIGEMASA (JP)
International Classes:
A01K67/027; G01N33/15; C12N15/09
Foreign References:
| JP2008539771A | 2008-11-20 | |||
| JP2000312544A | 2000-11-14 |
Other References:
TAKEI M ET AL.: "Detection of Epstein-Barr virus- encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients.", INT IMMUNOL., vol. 9, no. 5, 1997, pages 739 - 743, XP002929121, DOI: doi:10.1093/intimm/9.5.739
TAKEDA T ET AL.: "Lytic Epstein-Barr virus infection in the synovial tissue of patients with rheumatoid arthritis.", ARTHRITIS RHEUM., vol. 43, no. 6, 2000, pages 1218 - 1225
TOUSSIROT E ET AL.: "Pathophysiological links between rheumatoid arthritis and the Epstein- Barr virus: An update.", JOINT BONE SPINE, vol. 74, no. 5, 2007, pages 418 - 426, XP022308292
MASAMI TAKEI ET AL.: "The possible curative therapy for rheumatoid arthritis-EBV infection control gene SAP and its application", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 31, no. 3, 2008, pages 141 - 151
YOSHIO KOYANAGI ET AL.: "HIV Kansen Model Dobutsu to shite no Hito Zoketsu Saibo Ishoku SCID Mouse no Kaihatsu", THE JAPANESE SOCIETY OF VIROLOGY GAKUJUTSU SHUKAI PROGRAM SHOROKU- SHU, vol. 54, 2006, pages 185, 1C29
MASAMI TAKEI ET AL.: "Men'eki Idenshi SAP/ SH2D1A to sono Tanpaku Dai 4 Kai Kansetsu Rheumatism ni Okeru SAP Ijo", INFLAMMATION & IMMUNOLOGY, vol. 16, no. 4, 2008, pages 453 - 456
SAAL JG ET AL.: "Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope.", ARTHRITIS RHEUM., vol. 42, no. 7, 1999, pages 1485 - 1496
TAKEDA T ET AL.: "Lytic Epstein-Barr virus infection in the synovial tissue of patients with rheumatoid arthritis.", ARTHRITIS RHEUM., vol. 43, no. 6, 2000, pages 1218 - 1225
TOUSSIROT E ET AL.: "Pathophysiological links between rheumatoid arthritis and the Epstein- Barr virus: An update.", JOINT BONE SPINE, vol. 74, no. 5, 2007, pages 418 - 426, XP022308292
MASAMI TAKEI ET AL.: "The possible curative therapy for rheumatoid arthritis-EBV infection control gene SAP and its application", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 31, no. 3, 2008, pages 141 - 151
YOSHIO KOYANAGI ET AL.: "HIV Kansen Model Dobutsu to shite no Hito Zoketsu Saibo Ishoku SCID Mouse no Kaihatsu", THE JAPANESE SOCIETY OF VIROLOGY GAKUJUTSU SHUKAI PROGRAM SHOROKU- SHU, vol. 54, 2006, pages 185, 1C29
MASAMI TAKEI ET AL.: "Men'eki Idenshi SAP/ SH2D1A to sono Tanpaku Dai 4 Kai Kansetsu Rheumatism ni Okeru SAP Ijo", INFLAMMATION & IMMUNOLOGY, vol. 16, no. 4, 2008, pages 453 - 456
SAAL JG ET AL.: "Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope.", ARTHRITIS RHEUM., vol. 42, no. 7, 1999, pages 1485 - 1496
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Hiroshi Kobayashi (JP)
Hiroshi Kobayashi (JP)
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