Title:
HUMAN FIBROBLAST GROWTH FACTOR 21 (HFGF21) FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/032785
Kind Code:
A1
Abstract:
A fusion protein of hFGF21 or its analogs having improved pharmaceutical properties, and use of the fusion protein in preparing medicines for treating diseases, such as diabetes, obesity, non-alcoholic fatty liver disease, dyslipidemia, and/or metabolic syndrome.
Inventors:
DONG ZHAO (CN)
ZHOU CHI (CN)
FENG XIONG (CN)
LI ZIRUI (CN)
LI YUANLI (CN)
LI QIANG (CN)
ZHOU CHI (CN)
FENG XIONG (CN)
LI ZIRUI (CN)
LI YUANLI (CN)
LI QIANG (CN)
Application Number:
PCT/CN2017/079871
Publication Date:
February 22, 2018
Filing Date:
April 10, 2017
Export Citation:
Assignee:
AMPSOURCE BIOPHARMA INC (CN)
International Classes:
A61K38/18; C07K19/00; A61P3/04; A61P3/06; A61P3/10; C12N5/10; C12N15/62; C12N15/63; C12N15/85
Domestic Patent References:
WO2005091944A2 | 2005-10-06 | |||
WO2006050247A2 | 2006-05-11 | |||
WO2008121563A2 | 2008-10-09 | |||
WO2012066075A1 | 2012-05-24 | |||
WO2010084169A2 | 2010-07-29 | |||
WO2012010553A1 | 2012-01-26 | |||
WO2011071783A1 | 2011-06-16 | |||
WO2011130417A2 | 2011-10-20 | |||
WO2012158704A1 | 2012-11-22 | |||
WO2012170438A2 | 2012-12-13 | |||
WO2004110472A2 | 2004-12-23 | |||
WO2005113606A2 | 2005-12-01 | |||
WO2009149171A2 | 2009-12-10 | |||
WO2010042747A2 | 2010-04-15 | |||
WO2010129503A1 | 2010-11-11 | |||
WO2010129600A2 | 2010-11-11 | |||
WO2013049247A1 | 2013-04-04 | |||
WO2013188181A1 | 2013-12-19 | |||
WO2016114633A1 | 2016-07-21 | |||
WO2005058953A2 | 2005-06-30 | |||
WO2003011213A2 | 2003-02-13 | |||
WO2006065582A2 | 2006-06-22 | |||
WO2003061712A1 | 2003-07-31 | |||
WO2006028595A2 | 2006-03-16 | |||
WO2006028714A1 | 2006-03-16 |
Foreign References:
CN106317226A | 2017-01-11 | |||
CN106256835A | 2016-12-28 | |||
CN106279436A | 2017-01-04 | |||
CN106279437A | 2017-01-04 | |||
CN106117370A | 2016-11-16 | |||
CN103945871A | 2014-07-23 | |||
CN104693270A | 2015-06-10 | |||
CN104114183A | 2014-10-22 | |||
CN103539860A | 2014-01-29 | |||
CN103328502A | 2013-09-25 | |||
CN103539860A | 2014-01-29 | |||
CN103539861A | 2014-01-29 | |||
CN103539869A | 2014-01-29 | |||
US20010012628A1 | 2001-08-09 | |||
CN201280031137A | 2012-06-25 | |||
KR101027427B1 | 2011-04-11 | |||
KR20100099179A | 2010-09-10 | |||
CN201280066663A | 2012-12-28 | |||
US4399216A | 1983-08-16 | |||
US4818679A | 1989-04-04 |
Other References:
MOORE DD, SCIENCE, vol. 316, 2007, pages 1436 - 1438
BEENKEN, NATURE REVIEWS DRUG DISCOVER, vol. 8, 2009, pages 235
YIE J, FEBS LETT, vol. 583, no. 1, 2009, pages 19 - 24
MICANOVIC R, J CELL PHYSIOL, vol. 219, no. 2, 2009, pages 227 - 234
KHARITONENKOV A, JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 6, 2005, pages 1627 - 1635
COSKUN T, ENDOCRINOLOGY, vol. 149, no. 12, 2008, pages 6018 - 6027
XU J, DIABETES, vol. 58, no. 1, 2009, pages 250 - 259
BERGLUND ED, ENDOCRINOLOGY, vol. 150, no. 9, 2009, pages 4084 - 4093
XU J, AM J PHYSIOL ENDOCRINOL METAB, vol. 297, no. 5, 2009, pages E1105 - 1104
KHARITONENKOV A, ENDOCRINOLOGY, vol. 148, no. 2, 2007, pages 774 - 781
PAUL R ET AL., J BIOL CHEM, vol. 279, 2004, pages 6213 - 6216
SHIELDS RL ET AL., J BIOL CHEM, vol. 276, no. 9, 2001, pages 6591 - 604
"UNIPROT", Database accession no. Q9NSA1
YIE J. ET AL., FEBS LETTS, vol. 583, 2009, pages 19 - 24
FARES FA ET AL., PROC NATL ACAD SCI USA, vol. 89, 1992, pages 4304 - 4308
JEFFERIS R ET AL., IMMUNOL REV, vol. 163, 1998, pages 59 - 76
ROOPENIAN ET AL., NAT.REVIEW IMMUNOLOGY, vol. 7, 2007, pages 715 - 725
PAUL R. HINTON ET AL., J IMMUNOL, vol. 176, 2006, pages 346 - 356
DATTA-MANNAN A ET AL.: "MAbs", vol. 4, 2012, TAYLOR & FRANCIS, pages: 267 - 273
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
OLANDER RM, DEV BIOL STAND, vol. 86, 1996, pages 338
See also references of EP 3620474A4
BEENKEN, NATURE REVIEWS DRUG DISCOVER, vol. 8, 2009, pages 235
YIE J, FEBS LETT, vol. 583, no. 1, 2009, pages 19 - 24
MICANOVIC R, J CELL PHYSIOL, vol. 219, no. 2, 2009, pages 227 - 234
KHARITONENKOV A, JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 6, 2005, pages 1627 - 1635
COSKUN T, ENDOCRINOLOGY, vol. 149, no. 12, 2008, pages 6018 - 6027
XU J, DIABETES, vol. 58, no. 1, 2009, pages 250 - 259
BERGLUND ED, ENDOCRINOLOGY, vol. 150, no. 9, 2009, pages 4084 - 4093
XU J, AM J PHYSIOL ENDOCRINOL METAB, vol. 297, no. 5, 2009, pages E1105 - 1104
KHARITONENKOV A, ENDOCRINOLOGY, vol. 148, no. 2, 2007, pages 774 - 781
PAUL R ET AL., J BIOL CHEM, vol. 279, 2004, pages 6213 - 6216
SHIELDS RL ET AL., J BIOL CHEM, vol. 276, no. 9, 2001, pages 6591 - 604
"UNIPROT", Database accession no. Q9NSA1
YIE J. ET AL., FEBS LETTS, vol. 583, 2009, pages 19 - 24
FARES FA ET AL., PROC NATL ACAD SCI USA, vol. 89, 1992, pages 4304 - 4308
JEFFERIS R ET AL., IMMUNOL REV, vol. 163, 1998, pages 59 - 76
ROOPENIAN ET AL., NAT.REVIEW IMMUNOLOGY, vol. 7, 2007, pages 715 - 725
PAUL R. HINTON ET AL., J IMMUNOL, vol. 176, 2006, pages 346 - 356
DATTA-MANNAN A ET AL.: "MAbs", vol. 4, 2012, TAYLOR & FRANCIS, pages: 267 - 273
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
OLANDER RM, DEV BIOL STAND, vol. 86, 1996, pages 338
See also references of EP 3620474A4
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