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Title:
HUMAN FIBROBLAST GROWTH FACTOR 21 (HFGF21) FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/032785
Kind Code:
A1
Abstract:
A fusion protein of hFGF21 or its analogs having improved pharmaceutical properties, and use of the fusion protein in preparing medicines for treating diseases, such as diabetes, obesity, non-alcoholic fatty liver disease, dyslipidemia, and/or metabolic syndrome.

Inventors:
DONG ZHAO (CN)
ZHOU CHI (CN)
FENG XIONG (CN)
LI ZIRUI (CN)
LI YUANLI (CN)
LI QIANG (CN)
Application Number:
PCT/CN2017/079871
Publication Date:
February 22, 2018
Filing Date:
April 10, 2017
Export Citation:
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Assignee:
AMPSOURCE BIOPHARMA INC (CN)
International Classes:
A61K38/18; C07K19/00; A61P3/04; A61P3/06; A61P3/10; C12N5/10; C12N15/62; C12N15/63; C12N15/85
Domestic Patent References:
WO2005091944A22005-10-06
WO2006050247A22006-05-11
WO2008121563A22008-10-09
WO2012066075A12012-05-24
WO2010084169A22010-07-29
WO2012010553A12012-01-26
WO2011071783A12011-06-16
WO2011130417A22011-10-20
WO2012158704A12012-11-22
WO2012170438A22012-12-13
WO2004110472A22004-12-23
WO2005113606A22005-12-01
WO2009149171A22009-12-10
WO2010042747A22010-04-15
WO2010129503A12010-11-11
WO2010129600A22010-11-11
WO2013049247A12013-04-04
WO2013188181A12013-12-19
WO2016114633A12016-07-21
WO2005058953A22005-06-30
WO2003011213A22003-02-13
WO2006065582A22006-06-22
WO2003061712A12003-07-31
WO2006028595A22006-03-16
WO2006028714A12006-03-16
Foreign References:
CN106317226A2017-01-11
CN106256835A2016-12-28
CN106279436A2017-01-04
CN106279437A2017-01-04
CN106117370A2016-11-16
CN103945871A2014-07-23
CN104693270A2015-06-10
CN104114183A2014-10-22
CN103539860A2014-01-29
CN103328502A2013-09-25
CN103539860A2014-01-29
CN103539861A2014-01-29
CN103539869A2014-01-29
US20010012628A12001-08-09
CN201280031137A2012-06-25
KR101027427B12011-04-11
KR20100099179A2010-09-10
CN201280066663A2012-12-28
US4399216A1983-08-16
US4818679A1989-04-04
Other References:
MOORE DD, SCIENCE, vol. 316, 2007, pages 1436 - 1438
BEENKEN, NATURE REVIEWS DRUG DISCOVER, vol. 8, 2009, pages 235
YIE J, FEBS LETT, vol. 583, no. 1, 2009, pages 19 - 24
MICANOVIC R, J CELL PHYSIOL, vol. 219, no. 2, 2009, pages 227 - 234
KHARITONENKOV A, JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 6, 2005, pages 1627 - 1635
COSKUN T, ENDOCRINOLOGY, vol. 149, no. 12, 2008, pages 6018 - 6027
XU J, DIABETES, vol. 58, no. 1, 2009, pages 250 - 259
BERGLUND ED, ENDOCRINOLOGY, vol. 150, no. 9, 2009, pages 4084 - 4093
XU J, AM J PHYSIOL ENDOCRINOL METAB, vol. 297, no. 5, 2009, pages E1105 - 1104
KHARITONENKOV A, ENDOCRINOLOGY, vol. 148, no. 2, 2007, pages 774 - 781
PAUL R ET AL., J BIOL CHEM, vol. 279, 2004, pages 6213 - 6216
SHIELDS RL ET AL., J BIOL CHEM, vol. 276, no. 9, 2001, pages 6591 - 604
"UNIPROT", Database accession no. Q9NSA1
YIE J. ET AL., FEBS LETTS, vol. 583, 2009, pages 19 - 24
FARES FA ET AL., PROC NATL ACAD SCI USA, vol. 89, 1992, pages 4304 - 4308
JEFFERIS R ET AL., IMMUNOL REV, vol. 163, 1998, pages 59 - 76
ROOPENIAN ET AL., NAT.REVIEW IMMUNOLOGY, vol. 7, 2007, pages 715 - 725
PAUL R. HINTON ET AL., J IMMUNOL, vol. 176, 2006, pages 346 - 356
DATTA-MANNAN A ET AL.: "MAbs", vol. 4, 2012, TAYLOR & FRANCIS, pages: 267 - 273
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
OLANDER RM, DEV BIOL STAND, vol. 86, 1996, pages 338
See also references of EP 3620474A4
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