HUMAN GROWTH HORMONE FUSION PROTEIN AND ITS USE THEREOF - SHENZHEN KEXING PHARMACEUTICAL CO LTD

Title:

HUMAN GROWTH HORMONE FUSION PROTEIN AND ITS USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/093020

Kind Code:

A1

Abstract:

Provided are an Fc fragment mutant, a fusion protein, a nucleic acid molecule, an expression vector, a recombinant cell, a pharmaceutical composition and use thereof, and a method for preventing and/or treating a disease associated with abnormal growth hormone. The Fc fragment mutant has an amino acid sequence as shown in any one of SEQ ID NOs: 2 to 5; the fusion protein comprises: a second peptide comprising a bioactive molecular functional region, and a third peptide connected with the second peptide, the third peptide comprising an Fc fragment mutant according to any one of the above-mentioned Fc fragment mutant.

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Inventors:

QIN SUOFU (CN)
YAN CHENGWEI (CN)
PAN ZHIFU (CN)
WU FENGMEI (CN)
ZHOU DONGMEI (CN)
LI JUAN (CN)

Application Number:

PCT/CN2022/100113

Publication Date:

June 01, 2023

Filing Date:

June 21, 2022

Export Citation:

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Assignee:

SHENZHEN KEXING PHARMACEUTICAL CO LTD (CN)

International Classes:

C07K19/00; A61K38/27; A61K47/68; A61P5/06; C12N5/10; C12N15/62; C12N15/85

Domestic Patent References:

WO2018145075A1	2018-08-09
WO2020263830A1	2020-12-30

Foreign References:

CN108794634A	2018-11-13
CN110256575A	2019-09-20
CN103703129A	2014-04-02
CN112574315A	2021-03-30
CN105229035A	2016-01-06

Other References:

CHANG HOON LEE; JUNG HEE WOO; KWANG KEUN CHO; SEUNG HA KANG; SANG KEE KANG; YUN JAIE CHOI: "Expression and characterization of human growth hormone–Fc fusion proteins for transcytosis induction", BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, ACADEMIC PRESS, US, vol. 46, no. 4, 23 December 2010 (2010-12-23), US , pages 211 - 217, XP071712661, ISSN: 0885-4513, DOI: 10.1042/BA20060083
SU JIN KIM, KWAK HYUN-HEE, CHO SUNG YOON, SOHN YOUNG BAE, PARK SUNG WON, HUH RIMM, KIM JINSUP, KO AH-RA, JIN DONG-KYU: "Pharmacokinetics, Pharmacodynamics, and Efficacy of a Novel Long-Acting Human Growth Hormone: Fc Fusion Protein", MOLECULAR PHARMACEUTICS,VOL. 12, N. 10, 5 October 2015 (2015-10-05), pages 3759 - 3765, XP055575158, Retrieved from the Internet [retrieved on 20190328], DOI: 10.1021/acs.molpharmaceut.5b00550

Attorney, Agent or Firm:

ZHIFAN & PARTNERS (CN)

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