HUMAN IMMUNE INTERFERON PROTEIN AND PROCESS FOR ITS PREPARATION

Title:

HUMAN IMMUNE INTERFERON PROTEIN AND PROCESS FOR ITS PREPARATION

Document Type and Number:

WIPO Patent Application WO/1984/002129

Kind Code:

A1

Abstract:

Substantially pure human immune interferon protein having a specific activity of 107 U/mg or more, and a process for preparing the same from a culture liquor of transformed cells containing DNA which has a human immune interferon-coding base sequence. The human immune interferon is obtained by destroying cells recovered from a culture liquor and purifying the resulting solution containing human immune interferon using anti-human immune interferon monoclonal antibody. The transformed cells are obtained by introducing recombinant DNA molecule into host cells. The human immune interferon protein can be used as antiviral agent and antitumor agent.

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Inventors:

KIKUCHI MASAKAZU (JP)
TSUKAMOTO KYOZO (JP)
KUROKAWA TSUTOMU (JP)

Application Number:

PCT/JP1982/000445

Publication Date:

June 07, 1984

Filing Date:

November 22, 1982

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)

International Classes:

A61K38/21; A61P31/12; A61P35/00; A61P37/04; A61P43/00; A61K9/08; C07K1/16; C07K1/20; C07K1/22; C07K14/00; C07K14/52; C07K14/555; C07K14/57; C07K16/00; C07K16/24; C12N1/20; C12N15/02; C12N15/09; C12N15/70; C12N15/71; C12P21/00; C12P21/02; C12P21/08; A61K38/00; C12R1/19; C12R1/91; A61K; (IPC1-7): C07C7/00; C12P21/00; A61K45/02; C07C103/52

Foreign References:

JPS5813397A

1983-01-25

Other References:

Nature, Vol. 295, No. 11 (February, 1982) Patrick W. Gray, et al: "Expression of human immune interferon c DNA in E. coli and monkey cells" P. 503-508
Nature, Vol. 296, No. 18, (March, 1982) H.K. Hochkeppel, et al: "Monoclonal antibody against human IFN-gamma" P. 258-259
Ishikawa Kunihiko - Henshu "Bessatsu Tanpakushitsu Kakusan Koso Interferon Kekyu no Shinpo" 1. December. 1981 (01.12.81) Kyoritsu Shuppan Kabushiki Kaisha P. 64-65

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