HUMAN INTERLEUKIN-2 VARIANT AND USE THEREOF - XIAN LONGTENGJINGYUN BIOTECHNOLOGY CO LTD

Title:

HUMAN INTERLEUKIN-2 VARIANT AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/005680

Kind Code:

A1

Abstract:

Provided are a human interleukin-2 variant and the use thereof. Specifically, provided is an IL-2 variant (or a derivative thereof) having eliminated or reduced affinity with a high-affinity receptor IL-2Rα/β/γ and retaining affinity with a medium-affinity receptor IL-2Rβ/γ. Also provided is a recombinant protein/fusion protein comprising an IL-2 variant and a human antibody fragment. The activity of the IL-2 variant is improved, and is close to the activity of a wild human IL-2.

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Inventors:

DONG MINGHUI (CN)
LU YONGTAO (CN)
LIU JIANGUANG (CN)

Application Number:

PCT/CN2022/105789

Publication Date:

February 02, 2023

Filing Date:

July 14, 2022

Export Citation:

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Assignee:

XIAN LONGTENGJINGYUN BIOTECHNOLOGY CO LTD (CN)
YUNQUAN BIOTECHNOLOGY BEIJING CO LTD (CN)

International Classes:

C07K14/55; A61K38/20; A61K47/68; A61P35/00; A61P37/00; C07K19/00; C12N15/62; C12N15/64; C12N15/70; C12N15/81

Domestic Patent References:

WO2020125743A1	2020-06-25
WO2009135615A2	2009-11-12
WO2012062228A2	2012-05-18

Foreign References:

CN114369153A	2022-04-19
CN111647068A	2020-09-11
CN113831402A	2021-12-24
CN112105633A	2020-12-18
CN104231068A	2014-12-24
CN202110868409A	2021-07-30
CN202210621425A	2022-06-01
US8906356B2	2014-12-09
US9732134B2	2017-08-15
US7803361B2	2010-09-28
US8124066B2	2012-02-28

Other References:

CHANG RUIXUE, YAN TIAN-HUA, WANG QIU-JUAN, GUO QING-LONG: "Advances in Application of Interleukin-2 and Its Related Drugs ", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 35, no. 1, 25 January 2011 (2011-01-25), CN , pages 1 - 7, XP093028922, ISSN: 1001-5094, DOI: 10.3969/j.issn.1001-5094.2011.01.001
"Genbank", Database accession no. NP_000577.2

Attorney, Agent or Firm:

GE CHENG & CO., LTD (CN)

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