Title:
HUMAN MONOCLONAL ANTIBODIES BROADLY PROTECTIVE AGAINST INFLUENZA B VIRUS AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2013/114885
Kind Code:
A1
Abstract:
Materials and methods are provided for treating influenza B infections in humans. Anti-human influenza virus monoclonal antibodies and antigen-binding fragments thereof having a neutralization activity against a human influenza B virus are provided. Methods for producing anti-human influenza B virus monoclonal antibodies are also provided. The antibodies and antigen-binding fragments thereof can be effective against a wide range of influenza B viral strains. Methods of inhibiting or treating a human influenza B infection are provided. The anti-influenza B therapeutics can also be used to manufacture medicaments effective against influenza B infections, to detect human influenza B in a human subject, for use in pharmaceutical compositions, and for use in kits for at least one of the prevention, the treatment, and the detection of human influenza B in a human subject.
Inventors:
YASUGI MAYO (JP)
KUHARA MOTOKI (JP)
BOON-LONG JOTIKA (TH)
FUJIYAMA KAZUHITO (JP)
KOKETSU RITSUKO (JP)
IKUTA KAZUYOSHI (JP)
KUHARA MOTOKI (JP)
BOON-LONG JOTIKA (TH)
FUJIYAMA KAZUHITO (JP)
KOKETSU RITSUKO (JP)
IKUTA KAZUYOSHI (JP)
Application Number:
PCT/JP2013/000538
Publication Date:
August 08, 2013
Filing Date:
January 31, 2013
Export Citation:
Assignee:
UNIV OSAKA (JP)
UNIV OSAKA RES FOUND (JP)
MEDICAL & BIOL LAB CO LTD (JP)
DEPT OF MEDICAL SCIENCES (TH)
UNIV OSAKA RES FOUND (JP)
MEDICAL & BIOL LAB CO LTD (JP)
DEPT OF MEDICAL SCIENCES (TH)
International Classes:
C07K16/10; A61K39/395; A61P31/16; C12N15/02; C12P21/08; G01N33/569
Domestic Patent References:
| WO2010073647A1 | 2010-07-01 |
Other References:
KUBOTA-KOKETSU,R. ET AL.: "Broad neutralizing human monoclonal antibodies against influenza virus from vaccinated healthy donors.", BIOCHEM.BIOPHYS.RES.COMMUN., vol. 387, 2009, pages 180 - 185, XP026378974
NAKAGAWA,N.: "Antigenic Analysis of Influenza B pandemic strain.", INFLUENZA, vol. 8, no. 3, 2007, pages 203 - 208, XP008174737
See also references of EP 2814841A4
NAKAGAWA,N.: "Antigenic Analysis of Influenza B pandemic strain.", INFLUENZA, vol. 8, no. 3, 2007, pages 203 - 208, XP008174737
See also references of EP 2814841A4
Attorney, Agent or Firm:
SHOJI, Takashi et al. (Miyuki Bldg. 5-6-13, Nishinakajima, Yodogawa-ku, Osaka-sh, Osaka 11, JP)
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