Title:
HUMAN PAPILLOMAVIRUS TYPE 18 CHIMERIC PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/142523
Kind Code:
A1
Abstract:
The present invention relates to a human papillomavirus type 18 chimeric protein and the use thereof. Specifically, the present invention relates to a papillomavirus chimeric protein, which comprises or consists of an HPV type 18 L1 protein or a mutant of the HPV type 18 L1 protein, and a polypeptide from a HPV type 59 L2 protein inserted into the surface region of the HPV type 18 L1 protein or the mutant of the HPV type 18 L1 protein, wherein the amino acid sequence of the HPV type 18 L1 protein is as shown in SEQ ID NO. 1, and the amino acid sequence of the HPV type 59 L2 protein is as shown in SEQ ID NO. 2.
Inventors:
XU XUEMEI (CN)
ZHANG TING (CN)
WANG ZHIRONG (CN)
XIA BAICHENG (CN)
ZHANG TING (CN)
WANG ZHIRONG (CN)
XIA BAICHENG (CN)
Application Number:
PCT/CN2021/120583
Publication Date:
July 07, 2022
Filing Date:
September 26, 2021
Export Citation:
Assignee:
INST BASIC MEDICAL SCIENCES CAMS (CN)
International Classes:
C07K19/00; A61K39/12; A61P35/00; C12N5/10; C12N15/62
Foreign References:
| CN102497880A | 2012-06-13 | |||
| CN102153656A | 2011-08-17 | |||
| CN107188967A | 2017-09-22 | |||
| CN107188966A | 2017-09-22 | |||
| CN101835796A | 2010-09-15 | |||
| CN2017075402W | 2017-03-02 | |||
| CN104418942A | 2015-03-18 | |||
| CN108676057A | 2018-10-19 | |||
| CN101293918A | 2008-10-29 | |||
| CN101148661A | 2008-03-26 | |||
| CN104513826A | 2015-04-15 | |||
| CN1976718A | 2007-06-06 |
Other References:
DATABASE PROTEIN 11 October 2003 (2003-10-11), ANONYMOUS : "HPV18 major capsid protein L1 [synthetic construct]", XP055947681, retrieved from NCBI Database accession no. AAQ92369
DATABASE PROTEIN 8 September 2013 (2013-09-08), ANONYMOUS : "L2 [human papillomavirus 59]", XP055947682, retrieved from NCBI Database accession no. AGU90687
C. SCHELLENBACHER ET AL., THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 133, no. 12, 2013, pages 2706 - 13
H. SEITZ ET AL., VACCINE, vol. 32, no. 22, 2014, pages 2610 - 2617
B. HUBER ET AL., PLOS ONE, vol. 10, no. 3, 2015, pages e0120152
B. HUBER ET AL., PLOS ONE, vol. 12, no. 1, 2017, pages e0169533
X. CHEN ET AL., ONCOTARGET, vol. 8, no. 38, 2017, pages 63333 - 63344
X. CHEN ET AL., HUMAN VACCINES & IMMUNO- THERAPEUTICS, vol. 14, no. 8, 2018, pages 2025 - 2033
X. CHEN ET AL., HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 14, no. 8, 2018, pages 2025 - 2033
CAS, no. 25952-53-8
DATABASE PROTEIN 8 September 2013 (2013-09-08), ANONYMOUS : "L2 [human papillomavirus 59]", XP055947682, retrieved from NCBI Database accession no. AGU90687
C. SCHELLENBACHER ET AL., THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 133, no. 12, 2013, pages 2706 - 13
H. SEITZ ET AL., VACCINE, vol. 32, no. 22, 2014, pages 2610 - 2617
B. HUBER ET AL., PLOS ONE, vol. 10, no. 3, 2015, pages e0120152
B. HUBER ET AL., PLOS ONE, vol. 12, no. 1, 2017, pages e0169533
X. CHEN ET AL., ONCOTARGET, vol. 8, no. 38, 2017, pages 63333 - 63344
X. CHEN ET AL., HUMAN VACCINES & IMMUNO- THERAPEUTICS, vol. 14, no. 8, 2018, pages 2025 - 2033
X. CHEN ET AL., HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 14, no. 8, 2018, pages 2025 - 2033
CAS, no. 25952-53-8
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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