Title:
HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2018/103501
Kind Code:
A1
Abstract:
Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.
Inventors:
QI WEI (CN)
YU LEI (CN)
KANG LIQING (CN)
YU ZHOU (CN)
YU LEI (CN)
KANG LIQING (CN)
YU ZHOU (CN)
Application Number:
PCT/CN2017/110653
Publication Date:
June 14, 2018
Filing Date:
November 13, 2017
Export Citation:
Assignee:
SHANGHAI UNICAR THERAPY BIO MEDICINE TECH CO LTD (CN)
International Classes:
C12N15/113; A61K31/7088; A61K35/17; A61P35/00; C12N5/10; C12N15/66; C12N15/867
Domestic Patent References:
| WO2015023553A2 | 2015-02-19 |
Foreign References:
| CN107058315A | 2017-08-18 | |||
| CN106191062A | 2016-12-07 |
Other References:
ZHOU, XIANGJUN: "Accurate Treatment of Personalized Cancer: Clinical Application of Tumor Immunotherapy and Gene Sequencing Analysis", THE 14TH NATIONAL CONFERENCE OF TUMOR BIOTHERAPY CONFERENCE PROCEEDINGS, 15 May 2015 (2015-05-15), pages 12, XP009516870, Retrieved from the Internet
See also references of EP 3505631A4
See also references of EP 3505631A4
Attorney, Agent or Firm:
SHANGHAI HONGJING INTELLECTUAL PROPERTY AGENCY(GENERAL PARTNERSHIP) (CN)
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