Title:
HUMAN PLASMA CALCIUM ION ANTAGONIST-TANDEM MASS SPECTROMETRY DETECTION KIT
Document Type and Number:
WIPO Patent Application WO/2024/055447
Kind Code:
A1
Abstract:
The present invention relates to the technical field of calcium ion antagonist detection and provides a human plasma calcium ion antagonist-tandem mass spectrometry detection kit. The kit comprises a calibration material, a control material, an internal standard solution, an extraction agent, a QuEChERS purification material, a salting-out agent, a mobile phase A solution, a mobile phase B solution, a complex solution, a waterproof packaging bag, and a packaging box for separating and intensively packaging reagent bottles or tubes. The kit is high in sensitivity, high in specificity, and high in accuracy detection result, multiple CCBs with antihypertensive effects can be detected at the same time, and a CCBs direct detection method and kit are easy and convenient to operate and easy to popularize, so that the influence of a matrix effect and the instability of compound on an experimental result is reduced, thereby improving the clinical detection quality.
Inventors:
LI HUI (CN)
ZHAO TINGTING (CN)
ZHEN XIAOLAN (CN)
SHAO WENGANG (CN)
XING DIDI (CN)
ZHAO TINGTING (CN)
ZHEN XIAOLAN (CN)
SHAO WENGANG (CN)
XING DIDI (CN)
Application Number:
PCT/CN2022/138254
Publication Date:
March 21, 2024
Filing Date:
December 10, 2022
Export Citation:
Assignee:
HEBEI INST FOR DRUG AND MEDICAL DEVICE CONTROL HEBEI INST FOR COSMETICS CONTROL (CN)
UNIV HEBEI MEDICAL (CN)
UNIV HEBEI MEDICAL (CN)
International Classes:
G01N30/02; G01N30/06; G01N30/72; G01N30/86
Foreign References:
| CN115015406A | 2022-09-06 | |||
| CN108593828A | 2018-09-28 | |||
| CN104165937A | 2014-11-26 | |||
| CN110531014A | 2019-12-03 | |||
| CN104133006A | 2014-11-05 |
Other References:
BARANDA, A.B. ; ALONSO, R.M. ; JIMENEZ, R.M. ; WEINMANN, W.: "Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples", FORENSIC SCIENCE INTERNATIONAL, ELSEVIER B.V., AMSTERDAM, NL, vol. 156, no. 1, 6 January 2006 (2006-01-06), AMSTERDAM, NL , pages 23 - 34, XP027939802, ISSN: 0379-0738
Attorney, Agent or Firm:
SHIJIAZHUANG JUNLIAN PATENT AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
Download PDF: