HUMAN RAS INTERACTING PROTEIN

Title:

HUMAN RAS INTERACTING PROTEIN

Document Type and Number:

WIPO Patent Application WO2003054144

Kind Code:

A8

Abstract:

The invention provides isolated nucleic acids that encode a human Ras interacting protein (RasIn), including a shorter isoform (RasInS), and fragments thereof, vectors for propagating and expressing RasIn nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel RasIn isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human RasIn nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human RasIn gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the RasIn nucleic acids, proteins, and antibodies of the present invention.

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Inventors:

ZHANG JIAN (US)

Application Number:

PCT/US2002/035128

Publication Date:

July 19, 2007

Filing Date:

November 01, 2002

Export Citation:

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Assignee:

AMERSHAM PLC (GB)
ZHANG JIAN (US)

International Classes:

C07H21/04; A01K67/00; A61K39/395; A61K48/00; C07K14/00; C07K14/47; C07K16/00; C12N15/12; C12Q1/68; A61K38/00

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