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Title:
HUMAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
Document Type and Number:
WIPO Patent Application WO2001090151
Kind Code:
A3
Abstract:
Nucleic acids encoding mammalian, e.g., human receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

Inventors:
HARDIMAN GERARD T
ROCK FERNANDO L
BAZAN J FERNANDO
KASTELEIN ROBERT A
HO STEPHEN W K
LIU YONG-JUN
Application Number:
US0116766W
Publication Date:
October 17, 2002
Filing Date:
May 23, 2001
Export Citation:
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Assignee:
SCHERING CORPORATION
International Classes:
C12N15/09; A61K38/00; A61P37/00; A61P43/00; C07K14/705; C07K14/715; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12P21/08; C12Q1/02; F02D11/10; (IPC1-7): C07K14/705; C07K16/28; C12N15/12; C12N15/62; A61K38/17; A61K39/395; C12N5/10; C12N1/21
Domestic Patent References:
WO1998050547A21998-11-12
WO1999020756A21999-04-29
Other References:
ROCK FERNANDO L ET AL: "A family of human receptors structurally related to Drosophila toll." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 2, 20 January 1998 (1998-01-20), pages 588-593, XP002197052 Jan. 20, 1998 ISSN: 0027-8424 -& DATABASE EMBL [Online] EBI, Hinxton, UK; 3 October 1997 (1997-10-03) ROCK ET AL.: "Homo sapiens Toll-like receptor 2 (TLR2) mRNA, complete cds." Database accession no. U88878 XP002197054
CHAUDHARY PREET M ET AL: "Cloning and characterization of two toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans." BLOOD, vol. 91, no. 11, 1 June 1998 (1998-06-01), pages 4020-4027, XP002197053 ISSN: 0006-4971
See also references of EP 1283849A2
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