Title:
HUMAN TOXICOLOGICALLY RELEVANT GENES AND ARRAYS
Document Type and Number:
WIPO Patent Application WO2003016500
Kind Code:
A3
Abstract:
The invention provides for a set of toxicologically relevant human genes which may be used to predict toxicological responses on a cellular, organ, or system level. Methods of identifying, selecting, isolating, and evaluating toxicologically relevant human genes are provided. Arrays comprising human genes that are useful for toxicological screening of drugs, pharmaceutical compounds, or chemicals are also provided. The human array provides a method by which toxicological responses can analyzed in a rapid and efficient manner. Methods of identifying and isolating human genes for a human array are also provided. Further, methods of making a human gene array and using a human gene array are disclosed. These methods are also useful for isolating human genes and for discovery of novel human genes. Also provided is a database of human toxicological responses which are useful for predicting toxicological response to agents on a cellular level, organ-by-organ, and system-by-system. Methods of obtaining such databases containing human toxicological data and methods of use are also provided herein. Further, algorithms which allows for evaluation and/or 1 analysis of toxicological data are also provided herein.
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Inventors:
NEFT ROBIN E (US)
DUNN ROBERT T II (US)
ADKINS KARISSA (US)
PICKETT GAVIN G (US)
KIER LARRY D (US)
SCHMEISER KATJA (BE)
ALEN PHILLIPPE (BE)
DUNN ROBERT T II (US)
ADKINS KARISSA (US)
PICKETT GAVIN G (US)
KIER LARRY D (US)
SCHMEISER KATJA (BE)
ALEN PHILLIPPE (BE)
Application Number:
PCT/US2002/026514
Publication Date:
June 19, 2003
Filing Date:
August 16, 2002
Export Citation:
Assignee:
PHASE 1 MOLECULAR TOXICOLOGY I (US)
NEFT ROBIN E (US)
DUNN ROBERT T II (US)
ADKINS KARISSA (US)
PICKETT GAVIN G (US)
KIER LARRY D (US)
SCHMEISER KATJA (BE)
ALEN PHILLIPPE (BE)
NEFT ROBIN E (US)
DUNN ROBERT T II (US)
ADKINS KARISSA (US)
PICKETT GAVIN G (US)
KIER LARRY D (US)
SCHMEISER KATJA (BE)
ALEN PHILLIPPE (BE)
International Classes:
C12Q1/68; C12Q1/6883; (IPC1-7): C12Q1/68; C07H21/00; C07H21/04; C12M1/34; C12P19/34; C12Q1/68; G01N33/04; G01N33/50; G06F19/00
Foreign References:
| US6160105A | 2000-12-12 | |||
| US20020192671A1 | 2002-12-19 |
Other References:
See also references of EP 1427850A4
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