Title:
HUMAN TRANSFERRIN RECEPTOR-BINDING ANTIBODY-PEPTIDE CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2023/027125
Kind Code:
A1
Abstract:
[Problem] To provide an art for crossing the blood-brain barrier. [Solution] A conjugate comprising the following: (1) a transferrin receptor-binding peptide, wherein (i) the peptide contains the amino acid sequence from the 1st to the 15th (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Arg-Arg-Tyr-MeY-Cys) of the amino acid sequence given by SEQ ID NO: 1; (ii) the peptide has an amino acid sequence exhibiting a substitution, deletion, addition, and/or insertion of from 1 to 11 amino acid residues in the amino acid sequence from the 1st to the 15th of the amino acid sequence given by SEQ ID NO: 1; (iii) the peptide contains the amino acid sequence from the 1st to the 12th (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys) of the amino acid sequence given by SEQ ID NO: 14; or (iv) the peptide has an amino acid sequence exhibiting a substitution, deletion, addition, and/or insertion of from 1 to 8 amino acid residues in the amino acid sequence from the 1st to the 10th of the amino acid sequence given by SEQ ID NO: 14, and (2) a compound containing an antibody or an antigen-binding fragment thereof.
Inventors:
TAKAHASHI KENICHI (JP)
YODEN EIJI (JP)
HASHIMOTO HIDEHIKO (JP)
FUJIYAMA SAKI (JP)
OHUCHI MASAKI (JP)
SAWAI NAOKI (JP)
INABA SHINNOSUKE (JP)
YODEN EIJI (JP)
HASHIMOTO HIDEHIKO (JP)
FUJIYAMA SAKI (JP)
OHUCHI MASAKI (JP)
SAWAI NAOKI (JP)
INABA SHINNOSUKE (JP)
Application Number:
PCT/JP2022/031933
Publication Date:
March 02, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
PEPTIDREAM INC (JP)
JAPAN CHEM RES (JP)
JAPAN CHEM RES (JP)
International Classes:
C07K19/00; A61K38/10; A61K39/395; A61K47/68; A61P9/10; A61P17/02; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P31/04; A61P31/12; A61P35/00; C07K7/08; C07K16/00; C07K16/18; C12N15/62
Domestic Patent References:
| WO2020206093A1 | 2020-10-08 | |||
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Other References:
QIN XIN, ZHAO NING, ZHANG YING QI, YAN ZHEN: "Isolation and identification of a novel peptide binding to human transferrin receptor from phage-display library", JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY, vol. 25, no. 12, 1 January 2004 (2004-01-01), pages 1117 - 1119, XP009543761, ISSN: 2097-1656
XU DAN-DAN, HUANG YA-DONG, ZHANG QI-HAO, SU ZHI-JIAN, XU HUA, ZHENG QING: "Screening and identification of a novel transferrin receptor binding peptide", SHANDONG YIYAO - SHANDONG MEDICAL JOURNAL, SHANDONG SHENG WEISHENGTING,, CN, vol. 52, no. 11, 1 January 2012 (2012-01-01), CN , pages 15 - 18, XP009543790, ISSN: 1002-266X
MCQUAID CONOR, HALSEY ANDREA, DUBOIS MAËVA, ROMERO IGNACIO, MALE DAVID: "Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers", PLOS ONE, vol. 16, no. 6, 4 June 2021 (2021-06-04), pages e0252341, XP093010917, DOI: 10.1371/journal.pone.0252341
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
Y. GOTO ET AL., ACS CHEM. BIOL., vol. 3, 2008, pages 120 - 129
H. MURAKAMI, H. SAITO, AND H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 1077 - 1084
H. MURAKAMIA. OHTAH. ASHIGAIH. SUGA: "The flexizyme system: a highly flexible tRNA aminoacylation tool for the synthesis of nonnatural peptides", NATURE METHODS, vol. 3, 2006, pages 357 - 359
N. NIWAY. YAMAGISHIH. MURAKAMIH. SUGA: "A flexizyme that selectively charges amino acids activated by a water-friendly leaving group", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 3892 - 3894
K. J. JENSENP. T. SHELTONS. L. PEDERSEN: "Peptide Synthesis and Applications", 2013, SPRINGER
G. B. FIELDSR. L. NOBLE: "Solid Phase Peptide Synthesis Utilizing 9-Fluorenylmethoxycarbonyl Amino Acids", INT. J. PEPTIDE PROTEIN RES., vol. 35, 1990, pages 161 - 214
TEIXEIRA, W. E.BENCKHUIJSEN, P. E. DE KONINGA. R. P. M. VALENTIJNJ. W. DRIJFHOUT, PROTEIN PEPT. LETT., vol. 9, 2002, pages 379 - 385
XU DAN-DAN, HUANG YA-DONG, ZHANG QI-HAO, SU ZHI-JIAN, XU HUA, ZHENG QING: "Screening and identification of a novel transferrin receptor binding peptide", SHANDONG YIYAO - SHANDONG MEDICAL JOURNAL, SHANDONG SHENG WEISHENGTING,, CN, vol. 52, no. 11, 1 January 2012 (2012-01-01), CN , pages 15 - 18, XP009543790, ISSN: 1002-266X
MCQUAID CONOR, HALSEY ANDREA, DUBOIS MAËVA, ROMERO IGNACIO, MALE DAVID: "Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers", PLOS ONE, vol. 16, no. 6, 4 June 2021 (2021-06-04), pages e0252341, XP093010917, DOI: 10.1371/journal.pone.0252341
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
Y. GOTO ET AL., ACS CHEM. BIOL., vol. 3, 2008, pages 120 - 129
H. MURAKAMI, H. SAITO, AND H. SUGA, CHEMISTRY & BIOLOGY, vol. 10, 2003, pages 1077 - 1084
H. MURAKAMIA. OHTAH. ASHIGAIH. SUGA: "The flexizyme system: a highly flexible tRNA aminoacylation tool for the synthesis of nonnatural peptides", NATURE METHODS, vol. 3, 2006, pages 357 - 359
N. NIWAY. YAMAGISHIH. MURAKAMIH. SUGA: "A flexizyme that selectively charges amino acids activated by a water-friendly leaving group", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 3892 - 3894
K. J. JENSENP. T. SHELTONS. L. PEDERSEN: "Peptide Synthesis and Applications", 2013, SPRINGER
G. B. FIELDSR. L. NOBLE: "Solid Phase Peptide Synthesis Utilizing 9-Fluorenylmethoxycarbonyl Amino Acids", INT. J. PEPTIDE PROTEIN RES., vol. 35, 1990, pages 161 - 214
TEIXEIRA, W. E.BENCKHUIJSEN, P. E. DE KONINGA. R. P. M. VALENTIJNJ. W. DRIJFHOUT, PROTEIN PEPT. LETT., vol. 9, 2002, pages 379 - 385
Attorney, Agent or Firm:
HIROSE Takayuki (JP)
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