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Title:
HUMAN TYPE COMPLEMENTARITY DETERMINING REGION TRANSPLANTATION ANTIBODY AGAINST GANGLIOSIDE GD3 AND DERIVATIVES OF ANTIBODY AGAINST GANGLIOSIDE GD3
Document Type and Number:
WIPO Patent Application WO/2001/023432
Kind Code:
A1
Abstract:
A human type CDR transplantation antibody against ganglioside GD3 (hereinafter referred to as GD3); derivatives of the antiGD3 antibody with cytokines; and therapeutic and diagnostic utilization of the above-described antibody and derivatives.

Inventors:
Hanai, Nobuo (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Shitara, Kenya (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Nakamura, Kazuyasu (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Niwa, Rinpei (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Application Number:
PCT/JP2000/006774
Publication Date:
April 05, 2001
Filing Date:
September 29, 2000
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO CO., LTD. (6-1 Ohtemachi 1-chome Chiyoda-ku Tokyo, 100-8185, JP)
Hanai, Nobuo (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Shitara, Kenya (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Nakamura, Kazuyasu (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
Niwa, Rinpei (Tokyo Research Laboratories Kyowa Hakko Kogyo Co, Ltd. 6-6, Asahi-machi 3-chome Machida-shi Tokyo, 194-8533, JP)
International Classes:
A61P35/00; C07K16/18; C07K16/28; C12N15/13; C12P21/08; (IPC1-7): C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12P21/08
Foreign References:
JPH05304989A
Other References:
WEBBER K.O. ET AL.: 'Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-tac antibody: Comparison with its single-chain analog' MOLECULAR IMMUNOLOGY vol. 32, 1995, pages 249 - 258, XP002936310
MOUTEL S. ET AL.: 'Generation and characterization of a mouse single-chain antibody fragment specific for disialoganglioside (GD2)' HYBRIDOMA vol. 16, no. 4, 1997, pages 335 - 346, XP002936311
MORRISON S.L. ET AL.: 'Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains' PROC. NATL. ACAD. SCI. USA vol. 81, 1984, pages 6851 - 6855, XP002936312
JONES P.T. ET AL.: 'Replacing the complementarity-determing regions in a human antibody with those from a mouse' NATURE vol. 321, 1986, pages 522 - 525, XP002936313
See also references of EP 1238985A1
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