Title:
HUMANIZED ANTIBODIES AGAINST ICAM-1, THEIR PRODUCTION AND USES
Document Type and Number:
WIPO Patent Application WO2003035696
Kind Code:
A3
Abstract:
The invention provides humanized antibodies, for example, those that that bind ICAM-1, methods of use and methods of producing the antibodies. Antibodies include sequences having a VH and VL domain selected from HumA, HumB, HumC, HumD, HumE, HumF, HumG, HumH, HumI, Hum40 and Hum50.
Inventors:
FANG FANG (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHERINE HELEN (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHERINE HELEN (US)
Application Number:
PCT/US2002/023002
Publication Date:
November 27, 2003
Filing Date:
July 19, 2002
Export Citation:
Assignee:
PERLAN THERAPEUTICS INC (US)
FANG FANG (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHERINE HELEN (US)
FANG FANG (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHERINE HELEN (US)
International Classes:
C12N15/09; A61K39/395; A61P11/06; A61P31/04; A61P31/12; A61P33/06; C07K16/18; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/13; C12P21/08; (IPC1-7): C07K16/28; C07K16/46; C12N15/13; C12N15/63; A61K39/395; A61P31/12
Domestic Patent References:
| WO1991016927A1 | 1991-11-14 |
Other References:
FOOTE J ET AL: "ANTIBODY FRAMEWORK RESIDUES AFFECTING THE CONFORMATION OF THE HYPERVARIABLE LOOPS", JOURNAL OF MOLECULAR BIOLOGY, vol. 224, no. 2, 1992, pages 487 - 499, XP000564649, ISSN: 0022-2836
LUO GUANG X ET AL: "Humanization of an anti-ICAM-1 antibody with over 50-fold affinity and functional improvement.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 275, no. 1-2, 2003, pages 31 - 40, XP004416747, ISSN: 0022-1759
CHARLES CATHERINE H ET AL: "Prevention of human rhinovirus infection by multivalent Fab molecules directed against ICAM-1.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 47, no. 5, 20 May 2003 (2003-05-20), pages 1503 - 1508, XP009015720, ISSN: 0066-4804
LUO GUANG X ET AL: "Humanization of an anti-ICAM-1 antibody with over 50-fold affinity and functional improvement.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 275, no. 1-2, 2003, pages 31 - 40, XP004416747, ISSN: 0022-1759
CHARLES CATHERINE H ET AL: "Prevention of human rhinovirus infection by multivalent Fab molecules directed against ICAM-1.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 47, no. 5, 20 May 2003 (2003-05-20), pages 1503 - 1508, XP009015720, ISSN: 0066-4804
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