HUMANIZED ANTIBODIES AND METHODS FOR FORMING HUMANIZED ANTIBODIES

Title:

HUMANIZED ANTIBODIES AND METHODS FOR FORMING HUMANIZED ANTIBODIES

Document Type and Number:

WIPO Patent Application WO1998045332

Kind Code:

A3

Abstract:

Humanized and variant anti-VEGF antibodies and various uses therefore are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro, and inhibit tumor growth in vivo.

Inventors:

WELLS JAMES A (US)
BACA MANUEL (US)
PRESTA LEONARD G (US)

Application Number:

PCT/US1998/006724

Publication Date:

December 03, 1998

Filing Date:

April 03, 1998

Export Citation:

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Assignee:

GENENTECH INC (US)
WELLS JAMES A (US)
BACA MANUEL (US)
PRESTA LEONARD G (US)

International Classes:

C12N15/09; A61K38/17; A61K39/395; A61P25/00; A61P27/02; A61P35/00; C07K16/18; C07K16/22; C07K16/46; C12N5/10; C12N15/02; C12N15/13; C12N15/66; C12P21/02; C12P21/08; A61K38/00; (IPC1-7): C07K16/00

Domestic Patent References:

WO1992022653A1	1992-12-23
WO1994004679A1	1994-03-03

Foreign References:

US5580723A	1996-12-03
GB2268744A	1994-01-19

Other References:

KIM ET AL.,: "Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo", NATURE, vol. 362, 1993, London, GB, pages 841, XP002013864
M.M. BENDIG: "Humanization of rodent monoclonal antibodies", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, vol. 8, 1995, New York, NY, US, pages 83 - 93, XP000647344
M. BACA ET AL.,: "Antibody humanization using monovalent phage display", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 16, 18 April 1997 (1997-04-18), pages 10678 - 10684, XP002077471

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