Title:
HUMANIZED MONOCLONAL ANTIBODY FOR RESTORING DYSFUNCTIONAL HUMAN T AND B CELLS AGAINST CANCER AND VIRAL INFECTION
Document Type and Number:
WIPO Patent Application WO/2023/083377
Kind Code:
A1
Abstract:
Provided are two fully humanized Δ42PD1-specific mAbs, specifically huCH101 and huCH34 at 97.0% humanness by CDR grafting. Provided is a method of using huCH101 and/or huCH34 to treat subjects in need of Δ42PD1-specific mAb, including subjects with cancer and/or infection.
Inventors:
CHEN ZHIWEI (CN)
ZHOU DONGYAN (CN)
LIU LI (CN)
ZHOU DONGYAN (CN)
LIU LI (CN)
Application Number:
PCT/CN2022/132000
Publication Date:
May 19, 2023
Filing Date:
November 15, 2022
Export Citation:
Assignee:
VERSITECH LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13
Foreign References:
| CN105431449A | 2016-03-23 | |||
| CN105950715A | 2016-09-21 |
Other References:
CHENG LIN: "Generation of anti-human Delta-42PD1 monoclonal antibodies and preliminary study on immune function of Delta-42PD1", DOCTORAL DISSERTATION, 1 May 2014 (2014-05-01), CN, pages 1 - 87, XP009545603
CHENG, L.ET AL: "Monoclonal antibodies specific to human Δ42PD1:A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis", MABS NO.3 VOL.7, 1 May 2015 (2015-05-01), pages 620 - 629, XP055285201, DOI: 10.1080/19420862.2015.1016695
CHENG LIN, WANG ZI-QIAO,XU LIU-MEI,TANG XIAN, ZHOU YANG, WANG HUI: "Analysis of immunogenicity of △42PD1 via yeast surface displaying peptide frag-ments", CHINESE JOURNAL OF IMMUNOLOGY, vol. 32, no. 9, 26 January 2016 (2016-01-26), pages 1333 - 1337, XP093066963, DOI: 10.3969/j.issn.1000-484X.2016.09.019
ZHOU JINGYING; CHEUNG ALLEN K L; LIU HENGGUI; TAN ZHIWU; TANG XIAN; KANG YUANXI; DU YANHUA; WANG HAIBO; LIU LI; CHEN ZHIWEI: "Potentiating Functional Antigen-specific CD8(+) T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 21, no. 7, 1 July 2013 (2013-07-01), US , pages 1445 - 1455, XP009175152, ISSN: 1525-0016, DOI: 10.1038/mt.2013.63
CHENG, L.ET AL: "Monoclonal antibodies specific to human Δ42PD1:A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis", MABS NO.3 VOL.7, 1 May 2015 (2015-05-01), pages 620 - 629, XP055285201, DOI: 10.1080/19420862.2015.1016695
CHENG LIN, WANG ZI-QIAO,XU LIU-MEI,TANG XIAN, ZHOU YANG, WANG HUI: "Analysis of immunogenicity of △42PD1 via yeast surface displaying peptide frag-ments", CHINESE JOURNAL OF IMMUNOLOGY, vol. 32, no. 9, 26 January 2016 (2016-01-26), pages 1333 - 1337, XP093066963, DOI: 10.3969/j.issn.1000-484X.2016.09.019
ZHOU JINGYING; CHEUNG ALLEN K L; LIU HENGGUI; TAN ZHIWU; TANG XIAN; KANG YUANXI; DU YANHUA; WANG HAIBO; LIU LI; CHEN ZHIWEI: "Potentiating Functional Antigen-specific CD8(+) T Cell Immunity by a Novel PD1 Isoform-based Fusion DNA Vaccine", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 21, no. 7, 1 July 2013 (2013-07-01), US , pages 1445 - 1455, XP009175152, ISSN: 1525-0016, DOI: 10.1038/mt.2013.63
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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