Title:
HYALURONIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/234376
Kind Code:
A1
Abstract:
A hyaluronic acid derivative into which a steryl group is introduced according to the present invention is such that a ratio A1/A2 of areas A1 and A2, calculated by the following method from a chromatogram derived through gel permeation chromatography measurement, is 0.90 or greator. A2 is an area value surrounded by: a curve from an intersection point (Ub), at which a perpendicular line drawn from a refractive index intensity maximum point (Kb) on a chromatogram of 50 kDa polyacrylic acid serving as a standard substance to a baseline (B) intersects a chromatogram of the hyaluronic acid derivative, to the end point of the chromatogram of the hyaluronic acid derivative; a perpendicular line drawn from the refractive index intensity maximum point (Kb) to the baseline (B); and the baseline (B). A1 is an area value surrounded by a curve from the starting point of the chromatogram of the hyaluronic acid derivative to the intersection point (Ub), a perpendicular line drawn from the refractive index intensity maximum point (Kb) to the baseline (B), and the baseline (B).
Inventors:
YABUUCHI KOHEI (JP)
NAKAI TAKASHI (JP)
MOMOSE FUMIYASU (JP)
SHIKU HIROSHI (珠玖 洋)
NAKAI TAKASHI (JP)
MOMOSE FUMIYASU (JP)
SHIKU HIROSHI (珠玖 洋)
Application Number:
PCT/JP2023/020372
Publication Date:
December 07, 2023
Filing Date:
May 31, 2023
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
UNIV MIE (JP)
UNIV MIE (JP)
International Classes:
C08B37/08; A61K39/00; A61K39/39; A61K47/36; A61P31/00; A61P35/00; A61P37/04
Domestic Patent References:
| WO2021157665A1 | 2021-08-12 | |||
| WO2020158771A1 | 2020-08-06 |
Other References:
YUTAKA MASUDA, HIROKI MATSUSHIMA, SETSUKO YAMANE, KIYOSHI ONUMA, SHINICHI SAWADA, YOSHIHIRO SASAKI, KAZUNARI AKIYOSHI: "1PB-030 Synthesis of Silica-Hydrophobized Hyaluronic Acid Hybrid Hydrogel", PROCEEDINGS OF THE 99TH ANNUAL SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KOBE, JAPAN; MARCH 16-19, 2019, vol. 99, 30 November 2018 (2018-11-30) - 19 March 2019 (2019-03-19), pages 1PB - 030, XP009538319
YAMANE, SETSUKO; OHNUMA, KIYOSHI; SAWADA, SHIN-ICHI; SASAKI, YOSHIHIRO; AKIYOSHI, KAZUNARI: "2B6-29 Synthesis of hydrophobized hyaluronic acid-calcium phosphate hybrid fine particle", PROCEEDINGS OF THE 96TH ANNUAL SPRING CONFERENCE OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KYOTANABE, JAPAN; MARCH 24-27, 2016, vol. 96, 30 November 2015 (2015-11-30) - 27 March 2016 (2016-03-27), pages 2B6 - 29, XP009538320
YAMANE, SETSUKO; OHNUMA, KIYOSHI; SAWADA, SHIN-ICHI; SASAKI, YOSHIHIRO; AKIYOSHI, KAZUNARI: "2B6-29 Synthesis of hydrophobized hyaluronic acid-calcium phosphate hybrid fine particle", PROCEEDINGS OF THE 96TH ANNUAL SPRING CONFERENCE OF THE CHEMICAL SOCIETY OF JAPAN (CSJ); KYOTANABE, JAPAN; MARCH 24-27, 2016, vol. 96, 30 November 2015 (2015-11-30) - 27 March 2016 (2016-03-27), pages 2B6 - 29, XP009538320
Attorney, Agent or Firm:
MATSUNUMA Yasushi et al. (JP)
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