HYBRID ANTICANCER PRODRUG SIMULTANEOUSLY PRODUCING CINNAMALDEHYDE AND QUINONE METHIDE AND METHOD FOR PREPARING SAME

Title:

HYBRID ANTICANCER PRODRUG SIMULTANEOUSLY PRODUCING CINNAMALDEHYDE AND QUINONE METHIDE AND METHOD FOR PREPARING SAME

Document Type and Number:

WIPO Patent Application WO/2015/102448

Kind Code:

A1

Abstract:

The present invention relates to a hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide. The hybrid anticancer prodrug according to the present invention sequentially releases quinone methide and cinnamaldehyde by H2O2 and acidic pH, and thus alkylates antioxidant GSH through the release of quinone methide, thereby inhibiting an antioxidative system and increasing oxidation stress, and generates and accumulates reactive oxygen species (ROS) through the release of cinnamaldehyde, thereby promoting apoptosis, and thus the hybrid anticancer prodrug according to the present invention can be favorably used as an anticancer drug by creating a synergetic anticancer effect through double stimulus-response and sequential treatment action in a cancer cell-specific manner.

Inventors:

KWON BYOUNG MOG (KR)
LEE DONG WON (KR)
NOH JOUNG YOUN (KR)
KWON BYENG SU (KR)
HAN DONG CHO (KR)

Application Number:

PCT/KR2015/000067

Publication Date:

July 09, 2015

Filing Date:

January 05, 2015

Export Citation:

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Assignee:

NAT UNIV CHONBUK IND COOP FOUND (KR)
KOREA RES INST OF BIOSCIENCE (KR)

International Classes:

C07D319/06; A61K31/357

Domestic Patent References:

WO2000033858A1	2000-06-15
WO2005065361A2	2005-07-21

Attorney, Agent or Firm:

KIM, SOON WOONG (KR)
김순웅 (KR)

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