Title:
HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/075048
Kind Code:
A3
Abstract:
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
Inventors:
LIU JUN O (US)
Application Number:
PCT/US2011/062471
Publication Date:
August 02, 2012
Filing Date:
November 29, 2011
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
LIU JUN O (US)
LIU JUN O (US)
International Classes:
C07D471/04; A61K31/4353; A61K31/436; C07D498/04; C07D498/14; C07D515/04
Foreign References:
| US20090253732A1 | 2009-10-08 | |||
| US6984635B1 | 2006-01-10 |
Other References:
ZHOU, Y. ET AL.: "Using the protein chip to screen agonists and antagonists of the androgen receptor", JOURNAL OF BIOMOLECULAR SCREENING, vol. 13, no. 4, 2008, pages 276 - 284, XP055111903
Attorney, Agent or Firm:
HAILE, Lisa, A. (4365 Executive Drive Suite 110, San Diego CA, US)
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