Title:
HYBRID MOLECULES MADE OF LIPIDS AND LIPID-ANALOGOUS COMPOUNDS AND USE THEREOF AS PHARMACEUTICAL OR COSMETIC PREPARATION
Document Type and Number:
WIPO Patent Application WO/2010/149384
Kind Code:
A3
Abstract:
The invention relates to hybrid molecules made of two lipids or lipid- analogous compounds which are linked to each other via their lipophilic end. The hybrid molecules thereby have at least one hydrophilic group at their hydrophilic end for increasing the hydration shell of the hybrid molecule. The hybrid molecules according to the invention can be used as pharmaceutical or as a cosmetic preparation.
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Inventors:
WOLF HANS-UWE (DE)
Application Number:
PCT/EP2010/003876
Publication Date:
May 12, 2011
Filing Date:
June 23, 2010
Export Citation:
Assignee:
WOLF HANS-UWE (DE)
International Classes:
C07J7/00; A61K8/68; A61K31/164; A61P17/00; A61Q19/00
Domestic Patent References:
| WO2007006549A2 | 2007-01-18 |
Other References:
RUNQUIST E A ET AL: "DESIGN, SYNTHESIS, AND CHARACTERIZATION OF BIS-PHOSPHATIDYLCHOLINE, A MECHANISTIC PROBE OF PHOSPHATIDYLCHOLINE TRANSFER PROTEIN CATALYTIC ACTIVITY", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, NL, vol. 940, no. 1, 1 January 1988 (1988-01-01), pages 10 - 20, XP008009479, ISSN: 0006-3002, DOI: DOI:10.1016/0005-2736(88)90003-X
FUSS MARTINA ET AL: "Carbohydrate-carbohydrate interaction prominence in 3D supramolecular self-assembly", JOURNAL OF PHYSICAL CHEMISTRY PART B: CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, AMERICAN CHEMICAL SOCIETY, US, vol. 112, no. 37, 18 September 2008 (2008-09-18), pages 11595 - 11600, XP008132030, ISSN: 1520-6106, DOI: DOI:10.1021/JP804191J
DIJKSTRA H P ET AL: "Transmission of Binding Information across Lipid Bilayers", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 13, no. 25, 27 August 2007 (2007-08-27), pages 7215 - 7222, XP002618006, ISSN: 0947-6539, [retrieved on 20070619], DOI: DOI:10.1002/CHEM.200601723
MAUE M ET AL: "Bifunctional Bisamphiphilic Transmembrane Building Blocks for Artificial Signal Transduction", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, no. 14 SPEC. ISS, 16 July 2008 (2008-07-16), pages 2247 - 2256, XP002618007, ISSN: 0039-7881, [retrieved on 20080702], DOI: DOI:10.1055/S-2008-1067155
FÉLÉTOU M ET AL: "Vascular endothelial growth factor and the in vivo increase in plasma extravasation in the hamster cheek pouch", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, BASINGSTOKE, HANTS; GB, vol. 132, no. 6, 1 March 2001 (2001-03-01), pages 1342 - 1348, XP002618008, ISSN: 0007-1188, [retrieved on 20090129], DOI: DOI:10.1038/SJ.BJP.0703941
HSIEH H-P ET AL: "Structural Effects in Novel Steroidal Polyamine-DNA Binding", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 26, 1 January 1994 (1994-01-01), pages 12077 - 12078, XP002618009, ISSN: 0002-7863, DOI: DOI:10.1021/JA00105A068
See also references of EP 2445922A2
FUSS MARTINA ET AL: "Carbohydrate-carbohydrate interaction prominence in 3D supramolecular self-assembly", JOURNAL OF PHYSICAL CHEMISTRY PART B: CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, AMERICAN CHEMICAL SOCIETY, US, vol. 112, no. 37, 18 September 2008 (2008-09-18), pages 11595 - 11600, XP008132030, ISSN: 1520-6106, DOI: DOI:10.1021/JP804191J
DIJKSTRA H P ET AL: "Transmission of Binding Information across Lipid Bilayers", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 13, no. 25, 27 August 2007 (2007-08-27), pages 7215 - 7222, XP002618006, ISSN: 0947-6539, [retrieved on 20070619], DOI: DOI:10.1002/CHEM.200601723
MAUE M ET AL: "Bifunctional Bisamphiphilic Transmembrane Building Blocks for Artificial Signal Transduction", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, no. 14 SPEC. ISS, 16 July 2008 (2008-07-16), pages 2247 - 2256, XP002618007, ISSN: 0039-7881, [retrieved on 20080702], DOI: DOI:10.1055/S-2008-1067155
FÉLÉTOU M ET AL: "Vascular endothelial growth factor and the in vivo increase in plasma extravasation in the hamster cheek pouch", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, BASINGSTOKE, HANTS; GB, vol. 132, no. 6, 1 March 2001 (2001-03-01), pages 1342 - 1348, XP002618008, ISSN: 0007-1188, [retrieved on 20090129], DOI: DOI:10.1038/SJ.BJP.0703941
HSIEH H-P ET AL: "Structural Effects in Novel Steroidal Polyamine-DNA Binding", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 116, no. 26, 1 January 1994 (1994-01-01), pages 12077 - 12078, XP002618009, ISSN: 0002-7863, DOI: DOI:10.1021/JA00105A068
See also references of EP 2445922A2
Attorney, Agent or Firm:
PFENNING, MEINIG & PARTNER GBR (Theresienhöhe 13, München, DE)
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