Title:
HYDRAZIDE COMPOUND AND KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/158841
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound capable of accelerating the proliferation of cells in cell culturing (particularly three-dimensional cell culturing). A hydrazide compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof or a composition containing the hydrazide compound or the salt can accelerate the proliferation of cells, the formation of spheres, the formation of a cyst and/or the formation of an organoid significantly, and can also inhibit the activity of a kinase such as LATS1 and LATS2 significantly.
Inventors:
NISHINO TAITO (JP)
AIHARA AYAKO (JP)
OTSUKA KEIICHIRO (JP)
IWAWAKI TAKUMI (JP)
MIKASHIMA TAKUMI (JP)
KAMAURA MASAHIRO (JP)
FUKAZAWA NATSUKI (JP)
NAKAJIMA HIROYUKI (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO TOSHIMASA (JP)
AIHARA AYAKO (JP)
OTSUKA KEIICHIRO (JP)
IWAWAKI TAKUMI (JP)
MIKASHIMA TAKUMI (JP)
KAMAURA MASAHIRO (JP)
FUKAZAWA NATSUKI (JP)
NAKAJIMA HIROYUKI (JP)
SHIGETA YUKIHIRO (JP)
IWAMOTO TOSHIMASA (JP)
Application Number:
PCT/JP2020/003311
Publication Date:
August 06, 2020
Filing Date:
January 30, 2020
Export Citation:
Assignee:
NISSAN CHEMICAL CORP (JP)
International Classes:
A61P1/04; A61K31/341; A61K31/381; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61P1/16; A61P9/10; A61P17/00; A61P17/02; A61P21/02; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P43/00; C07D213/40; C07D213/65; C07D213/74; C07D235/04; C07D239/28; C07D307/52; C07D333/20; C12N5/00; C12N5/07; C12N9/99
Domestic Patent References:
| WO2009154201A1 | 2009-12-23 | |||
| WO2019022222A1 | 2019-01-31 | |||
| WO2019117262A1 | 2019-06-20 | |||
| WO2019235569A1 | 2019-12-12 | |||
| WO2008155920A1 | 2008-12-24 | |||
| WO2018198077A2 | 2018-11-01 | |||
| WO2014017513A1 | 2014-01-30 | |||
| WO2016136986A1 | 2016-09-01 |
Foreign References:
| JP2018530594A | 2018-10-18 | |||
| US5990141A | 1999-11-23 | |||
| JPH11504000A | 1999-04-06 | |||
| US5994503A | 1999-11-30 | |||
| JP2019014899A | 2019-01-31 | |||
| JP2019103322A | 2019-06-24 |
Other References:
SUSAN BRESLIN, DRUG DISCOVERY TODAY, vol. 18, no. 5, 2013, pages 240 - 249
ROBERT ROSKOSKI JR., PHARMACOLOGICAL RESEARCH, vol. 100, 2016, pages 1 - 23
JUSTICE RW ET AL., GENES & DEVELOPMENT, vol. 9, no. 5, 1995, pages 534 - 546
HERGOVICH A, CELL & BIOSCIENCE, vol. 3, no. 1, 2013, pages 32
PEFANI DE ET AL., THE FEBS JOURNAL, vol. 283, no. 8, 2016, pages 1392 - 1403
MENG Z ET AL., GENES & DEVELOPMENT, vol. 30, no. 1, 2016, pages 1 - 17
ZHAO B ET AL., CURRENT OPINION IN CELL BIOLOGY, vol. 20, no. 6, 2008, pages 638 - 646
IMAJO M ET AL., THE EMBO JOURNAL, vol. 31, 2012, pages 1109 - 1122
SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 23, no. 7, 2012, pages 785 - 793
GUJRAL TS ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, no. 18, 2017, pages E3729 - E3738
LEE DH ET AL., NATURE COMMUNICATION, vol. 7, 2016, pages 11961
MOROISHI T ET AL., CELL, vol. 167, 2016, pages 1525 - 1539
AYLON Y ET AL., CELL DEATH & DIFFERENTIATION, vol. 21, no. 4, 2014, pages 624 - 633
JOHNSON R ET AL., NATURE REVIEWS DRUG DISCOVERY, vol. 13, no. 1, 2014, pages 63 - 79
LEACH JP ET AL., NATURE, vol. 550, no. 7675, 2017, pages 260 - 264
FAN F ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 8, no. 352, 2016, pages 352 - 108
YANG Z ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 34, no. 9, 2014, pages 1607 - 1621
SYNTHESIS, no. 13, 2002, pages 1857
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 298, no. 1, 2013, pages 9
NATURE BIOTECHNOLOGY, vol. 28, no. 4, 2010, pages 361 - 366
NATURE PROTOCOLS, vol. 6, no. 5, 2011, pages 572 - 579
STEM CELL RESEARCH, vol. 7, 2011, pages 97 - 111
STEM CELL REVIEWS AND REPORTS, vol. 6, 2010, pages 248 - 259
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 3915636A4
ROBERT ROSKOSKI JR., PHARMACOLOGICAL RESEARCH, vol. 100, 2016, pages 1 - 23
JUSTICE RW ET AL., GENES & DEVELOPMENT, vol. 9, no. 5, 1995, pages 534 - 546
HERGOVICH A, CELL & BIOSCIENCE, vol. 3, no. 1, 2013, pages 32
PEFANI DE ET AL., THE FEBS JOURNAL, vol. 283, no. 8, 2016, pages 1392 - 1403
MENG Z ET AL., GENES & DEVELOPMENT, vol. 30, no. 1, 2016, pages 1 - 17
ZHAO B ET AL., CURRENT OPINION IN CELL BIOLOGY, vol. 20, no. 6, 2008, pages 638 - 646
IMAJO M ET AL., THE EMBO JOURNAL, vol. 31, 2012, pages 1109 - 1122
SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 23, no. 7, 2012, pages 785 - 793
GUJRAL TS ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, no. 18, 2017, pages E3729 - E3738
LEE DH ET AL., NATURE COMMUNICATION, vol. 7, 2016, pages 11961
MOROISHI T ET AL., CELL, vol. 167, 2016, pages 1525 - 1539
AYLON Y ET AL., CELL DEATH & DIFFERENTIATION, vol. 21, no. 4, 2014, pages 624 - 633
JOHNSON R ET AL., NATURE REVIEWS DRUG DISCOVERY, vol. 13, no. 1, 2014, pages 63 - 79
LEACH JP ET AL., NATURE, vol. 550, no. 7675, 2017, pages 260 - 264
FAN F ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 8, no. 352, 2016, pages 352 - 108
YANG Z ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 34, no. 9, 2014, pages 1607 - 1621
SYNTHESIS, no. 13, 2002, pages 1857
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 298, no. 1, 2013, pages 9
NATURE BIOTECHNOLOGY, vol. 28, no. 4, 2010, pages 361 - 366
NATURE PROTOCOLS, vol. 6, no. 5, 2011, pages 572 - 579
STEM CELL RESEARCH, vol. 7, 2011, pages 97 - 111
STEM CELL REVIEWS AND REPORTS, vol. 6, 2010, pages 248 - 259
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 3915636A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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