Title:
HYDRAZIDE-CONTAINING CFTR INHIBITOR COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2005094374
Kind Code:
A3
Abstract:
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR.
More Like This:
Inventors:
VERKMAN ALAN (US)
SONAWANE NITIN DATTATRAYA (US)
MUANPRASAT CHATCHAI (TH)
SONAWANE NITIN DATTATRAYA (US)
MUANPRASAT CHATCHAI (TH)
Application Number:
PCT/US2005/010787
Publication Date:
September 08, 2006
Filing Date:
March 29, 2005
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
VERKMAN ALAN (US)
SONAWANE NITIN DATTATRAYA (US)
MUANPRASAT CHATCHAI (TH)
VERKMAN ALAN (US)
SONAWANE NITIN DATTATRAYA (US)
MUANPRASAT CHATCHAI (TH)
International Classes:
C07C251/86; A61K31/165; A61K31/195; A61K31/47; A61K31/7012; C07D215/38
Domestic Patent References:
| WO2001030333A2 | 2001-05-03 |
Foreign References:
| US6331555B1 | 2001-12-18 | |||
| EP0952159A2 | 1999-10-27 |
Other References:
AMINABHAVI ET AL.: "Synthesis and Characterization of Biologically Active Organosilicon and Organotin Complexes of Phenylglycyl Hydrazones", INORGANICA CHIMICA ACTA, vol. 135, no. 2, 1987, pages 139 - 143, XP009008389
VERMA M. ET AL.: "Syntheses and Anti-inflammatory Activities of Substituted Arylamino-[N'-benzylidene]acetohydrazides and Derivatives", ARCHIV. DER PHARMAZIE (WEINHEIM), vol. 317, no. 10, 1984, pages 890 - 894, XP003001850
CHEMICAL ABSTRACTS, vol. 55, no. 14, 10 July 1961, Columbus, Ohio, US; abstract no. 13350H-I, KONDO ET AL.: "N-Arylglycine Series Chemotherapeutics. I. Synthesis of Aryl Sulfone Derivatives" page 13350-51; XP002162400
VERMA M. ET AL.: "Syntheses and Anti-inflammatory Activities of Substituted Arylamino-[N'-benzylidene]acetohydrazides and Derivatives", ARCHIV. DER PHARMAZIE (WEINHEIM), vol. 317, no. 10, 1984, pages 890 - 894, XP003001850
CHEMICAL ABSTRACTS, vol. 55, no. 14, 10 July 1961, Columbus, Ohio, US; abstract no. 13350H-I, KONDO ET AL.: "N-Arylglycine Series Chemotherapeutics. I. Synthesis of Aryl Sulfone Derivatives" page 13350-51; XP002162400
Download PDF: