Title:
HYDRAZINE-BASED AND CARBONYL-BASED BIFUNCTIONAL CROSSLINKING REAGENTS
Document Type and Number:
WIPO Patent Application WO2001070685
Kind Code:
A3
Abstract:
Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
Inventors:
SCHWARTZ DAVID A (US)
Application Number:
PCT/US2001/009252
Publication Date:
March 27, 2003
Filing Date:
March 22, 2001
Export Citation:
Assignee:
SOLULINK INC (US)
SCHWARTZ DAVID A (US)
SCHWARTZ DAVID A (US)
International Classes:
A61K47/48; C07D207/452; C07D207/46; C07D213/82; C07D401/12; C07F7/18; C07H21/04; C07K1/107; C07K14/06; C07H21/02; C08G65/329; C08G65/336; C12N9/96; C07D207/44; (IPC1-7): C07D207/46; C07D401/12; C08G65/329; C07F7/18; C07D213/82; A61K47/48; C07K17/06; C07K17/14; C12N11/06; C12N11/14
Domestic Patent References:
| WO1986006073A1 | 1986-10-23 | |||
| WO2001009385A2 | 2001-02-08 | |||
| WO1994010149A1 | 1994-05-11 | |||
| WO1990010621A1 | 1990-09-20 | |||
| WO1995015769A1 | 1995-06-15 | |||
| WO1999052861A1 | 1999-10-21 | |||
| WO1990003401A1 | 1990-04-05 |
Foreign References:
| EP0665020A2 | 1995-08-02 | |||
| EP0326863A2 | 1989-08-09 | |||
| US4797491A | 1989-01-10 | |||
| GB782420A | 1957-09-04 | |||
| US4882399A | 1989-11-21 | |||
| US3180875A | 1965-04-27 | |||
| EP0384769A2 | 1990-08-29 |
Other References:
W.L. SCOTT ET AL, BIOORG. MED. CHEM. LETT., vol. 6, no. 13, 1996, pages 1491 - 1496, XP002202926
G. SZOKAN ET AL, J. CHIN. CHEM. SOC. (TAIPEI), vol. 44, no. 5, 1997, pages 519 - 526, XP000925994
T. CURTIUS ET AL, CHEM. BER., vol. 43, 1910, pages 2457 - 2467, XP002202927
D. GILLESSEN ET AL, DEV. ENDOCRINOL., vol. 13, 1981, pages 37 - 47, XP000926737
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223793
E. LUKEVITS ET AL, J. GEN. CHEM. USSR, vol. 47, 1977, pages 101 - 104, XP001041813
B. BLANK ET AL, J. MED. CHEM., vol. 17, no. 10, 1974, pages 1065 - 1071, XP002158204
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223794, retrieved from STN Database accession no. 1980:180407
J.R. NULU ET AL, TETRAHEDRON LETT., vol. 10, no. 17, 1969, pages 1321 - 1324, XP001109223
O.P. SHVAIKA ET AL, SOV. PROG. CHEM., vol. 37, no. 2, 1971, pages 55 - 61, XP001040695
L. KATZ ET AL, J. ORG. CHEM., vol. 18, no. 10, 1953, pages 1380 - 1402, XP002223788
D.L. KLAYMAN ET AL, J. ORG. CHEM., vol. 33, no. 2, 1968, pages 884 - 887, XP002223789
R.R. WEBB II ET AL, BIOCONJUGATE CHEM, vol. 1, no. 2, 1990, pages 96 - 99, XP002223790
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223795, retrieved from STN Database accession no. 1988:38245
L. BAUER ET AL, J. ORG. CHEM., vol. 30, 1965, pages 949 - 951, XP002128002
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223796, retrieved from STN Database accession no. 1975:478986
M.A. BAKER ET AL, JOURNAL OF CONTROLLED RELEASE, vol. 40, no. 1-2, 1996, pages 89 - 100, XP000589917
T. KANEKO ET AL, BIOCONJUGATE CHEMISTRY, vol. 2, no. 3, 1991, pages 133 - 141, XP000215610
G. SZOKAN ET AL, J. CHIN. CHEM. SOC. (TAIPEI), vol. 44, no. 5, 1997, pages 519 - 526, XP000925994
T. CURTIUS ET AL, CHEM. BER., vol. 43, 1910, pages 2457 - 2467, XP002202927
D. GILLESSEN ET AL, DEV. ENDOCRINOL., vol. 13, 1981, pages 37 - 47, XP000926737
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223793
E. LUKEVITS ET AL, J. GEN. CHEM. USSR, vol. 47, 1977, pages 101 - 104, XP001041813
B. BLANK ET AL, J. MED. CHEM., vol. 17, no. 10, 1974, pages 1065 - 1071, XP002158204
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223794, retrieved from STN Database accession no. 1980:180407
J.R. NULU ET AL, TETRAHEDRON LETT., vol. 10, no. 17, 1969, pages 1321 - 1324, XP001109223
O.P. SHVAIKA ET AL, SOV. PROG. CHEM., vol. 37, no. 2, 1971, pages 55 - 61, XP001040695
L. KATZ ET AL, J. ORG. CHEM., vol. 18, no. 10, 1953, pages 1380 - 1402, XP002223788
D.L. KLAYMAN ET AL, J. ORG. CHEM., vol. 33, no. 2, 1968, pages 884 - 887, XP002223789
R.R. WEBB II ET AL, BIOCONJUGATE CHEM, vol. 1, no. 2, 1990, pages 96 - 99, XP002223790
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223795, retrieved from STN Database accession no. 1988:38245
L. BAUER ET AL, J. ORG. CHEM., vol. 30, 1965, pages 949 - 951, XP002128002
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002223796, retrieved from STN Database accession no. 1975:478986
M.A. BAKER ET AL, JOURNAL OF CONTROLLED RELEASE, vol. 40, no. 1-2, 1996, pages 89 - 100, XP000589917
T. KANEKO ET AL, BIOCONJUGATE CHEMISTRY, vol. 2, no. 3, 1991, pages 133 - 141, XP000215610
Download PDF:
Previous Patent: PEPTIDOMIMETIC LIGANDS FOR CELLULAR RECEPTORS AND ION CHANNELS
Next Patent: 5-HYDROXY INDOLE DERIVATIVES FOR TREATING GLAUCOMA
Next Patent: 5-HYDROXY INDOLE DERIVATIVES FOR TREATING GLAUCOMA