Title:
HYDRAZONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/084872
Kind Code:
A1
Abstract:
Disclosed is a hydrazone derivative represented by the formula [I] below or a pharmacologically acceptable salt thereof, which is useful as a glucokinase activator. (In the formula, ring A represents an aryl or a heteroaryl; T represents a heteroaryl or a heterocyclic group; R1 and R2 independently represent a hydrogen atom, a halogen atom, a cycloalkylsulfonyl group or the like; R3 and R4 represent a substituted or unsubstituted heterocyclic group formed together with an adjacent nitrogen atom; R5 represents a hydrogen atom, a halogen atom, a cyano, a nitro, a tetrazolyl or the like; and R6 represents a hydrogen atom or the like.)
Inventors:
TAKAMURO IWAO
SUGAWARA KAZUTOSHI
SUGAMA HIROSHI
SUGAWARA KAZUTOSHI
SUGAMA HIROSHI
Application Number:
PCT/JP2008/050466
Publication Date:
July 17, 2008
Filing Date:
January 09, 2008
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
TAKAMURO IWAO
SUGAWARA KAZUTOSHI
SUGAMA HIROSHI
TAKAMURO IWAO
SUGAWARA KAZUTOSHI
SUGAMA HIROSHI
International Classes:
C07D213/75; A61K31/422; A61K31/427; A61K31/433; A61K31/437; A61K31/4439; A61K31/454; A61K31/455; A61K31/497; A61K31/4995; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61P27/02; A61P43/00; C07D213/80; C07D239/42; C07D239/72; C07D241/20; C07D261/14; C07D277/20; C07D277/46; C07D277/56; C07D285/08; C07D285/135; C07D417/06; C07D417/12; C07D417/14; C07D487/08; C07D513/04
Domestic Patent References:
| WO2004072066A1 | 2004-08-26 | |||
| WO2007007886A1 | 2007-01-18 | |||
| WO2005044801A1 | 2005-05-19 | |||
| WO2004081001A1 | 2004-09-23 | |||
| WO2004076420A1 | 2004-09-10 | |||
| WO2004063194A1 | 2004-07-29 | |||
| WO2004063179A1 | 2004-07-29 | |||
| WO2004052869A1 | 2004-06-24 | |||
| WO2004050645A1 | 2004-06-17 | |||
| WO2003095438A1 | 2003-11-20 | |||
| WO2003055482A1 | 2003-07-10 | |||
| WO2002014312A1 | 2002-02-21 |
Foreign References:
| US4207234A | 1980-06-10 | |||
| JP2001199971A | 2001-07-24 |
Other References:
See also references of EP 2105435A4
AMERICAN JOURNAL PHYSIOLOGY, vol. 247, 1984, pages 527 - 536
CELL, vol. 83, 1995, pages 69 - 78
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., vol. 93, 1996, pages 7225 - 7230
NATURE GENETICS, vol. 356, 1992, pages 721 - 722
NEW ENGLAND JOURNAL OF MEDICINE, vol. 338, 1998, pages 226 - 230
DIABETES, vol. 48, no. 9, 1999, pages 1763 - 72
ORGANIC SYNTHESIS, vol. II, 1943, pages 211
ORGANIC SYNTHESIS, vol. II, 1943, pages 290
ORGANIC SYNTHESIS, vol. II, 1943, pages 418
ORGANIC SYNTHESIS, vol. II, 1943, pages 460
ORGANIC SYNTHESIS, vol. V, 1973, pages 893
ORGANIC SYNTHESIS, vol. V, 1988, pages 542
YOUNG R. N. ET AL., TETRAHEDRON LETT., vol. 25, no. 17, 1984, pages 1753
AMERICAN JOURNAL PHYSIOLOGY, vol. 247, 1984, pages 527 - 536
CELL, vol. 83, 1995, pages 69 - 78
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., vol. 93, 1996, pages 7225 - 7230
NATURE GENETICS, vol. 356, 1992, pages 721 - 722
NEW ENGLAND JOURNAL OF MEDICINE, vol. 338, 1998, pages 226 - 230
DIABETES, vol. 48, no. 9, 1999, pages 1763 - 72
ORGANIC SYNTHESIS, vol. II, 1943, pages 211
ORGANIC SYNTHESIS, vol. II, 1943, pages 290
ORGANIC SYNTHESIS, vol. II, 1943, pages 418
ORGANIC SYNTHESIS, vol. II, 1943, pages 460
ORGANIC SYNTHESIS, vol. V, 1973, pages 893
ORGANIC SYNTHESIS, vol. V, 1988, pages 542
YOUNG R. N. ET AL., TETRAHEDRON LETT., vol. 25, no. 17, 1984, pages 1753
Attorney, Agent or Firm:
NAKAMURA, Toshio et al. (MITSUBISHI TANABE PHARMA CORPORATION16-89, Kashima 3-chome, Yodogawa-ku, , Osaka-shi,O, saka, JP)
Download PDF: