Title:
HYDRAZONES AND ANALOGS AS CHOLESTEROL LOWERING AGENTS
Document Type and Number:
WIPO Patent Application WO2001064646
Kind Code:
A3
Abstract:
Hydrazones and hydrazone analogs are provided which are useful as upregulators of LDL receptors and can be used in the treatment of hypercholesterolemia and related disorders and conditions.
Inventors:
MEDINA JULIO C (US)
HASEGAWA HIROHIKO (JP)
HASEGAWA HIROHIKO (JP)
Application Number:
PCT/US2001/006810
Publication Date:
May 30, 2002
Filing Date:
March 01, 2001
Export Citation:
Assignee:
TULARIK INC (US)
SUMITOMO PHARMA (JP)
MEDINA JULIO C (US)
HASEGAWA HIROHIKO (JP)
SUMITOMO PHARMA (JP)
MEDINA JULIO C (US)
HASEGAWA HIROHIKO (JP)
International Classes:
A61P9/10; C07C251/86; C07D207/325; C07D209/14; C07D215/12; C07D215/14; C07D215/38; C07D307/52; C07D307/81; C07D311/22; C07D333/58; C07D409/04; C07D207/32; (IPC1-7): C07D215/38; A61K31/15; A61P9/10; C07C229/60; C07D207/32; C07D209/14; C07D215/12; C07D215/14; C07D307/52; C07D307/81; C07D311/22; C07D333/58; C07D409/04
Domestic Patent References:
| WO1993008171A1 | 1993-04-29 |
Foreign References:
| EP0889032A1 | 1999-01-07 | |||
| EP0451653A2 | 1991-10-16 | |||
| EP0382076A1 | 1990-08-16 | |||
| JPH06130434A | 1994-05-13 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; COUTINHO, DIONYSIA L. M. ET AL: "Synthesis and evaluation of potential pharmacophores derived from 4-oxo-4H-1-benzopyran-3-carboxyldehyde", XP002181833, retrieved from STN Database accession no. 118:212970
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RICOH CO., LTD., JAPAN: "Presensitized lithographic plates", XP002181834, retrieved from STN Database accession no. 101:31169
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KHALIL, M. A. ET AL: "Synthesis, antimicrobial, inotropic, and chronotropic activities of novel 1,2,4-triazolo[4,3-a]quinolines", XP002181835, retrieved from STN Database accession no. 115:49531
R.H. WILEY; R.L. CLEVENGER: "Aldehyde hydrazone derivatives in cancer chemotherapy", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY., vol. 5, 1962, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 1367 - 1371, XP002181832
DATABASE WPI Section Ch Week 199606, Derwent World Patents Index; Class B03, AN 1996-055961, XP002181836
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RICOH CO., LTD., JAPAN: "Presensitized lithographic plates", XP002181834, retrieved from STN Database accession no. 101:31169
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KHALIL, M. A. ET AL: "Synthesis, antimicrobial, inotropic, and chronotropic activities of novel 1,2,4-triazolo[4,3-a]quinolines", XP002181835, retrieved from STN Database accession no. 115:49531
R.H. WILEY; R.L. CLEVENGER: "Aldehyde hydrazone derivatives in cancer chemotherapy", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY., vol. 5, 1962, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 1367 - 1371, XP002181832
DATABASE WPI Section Ch Week 199606, Derwent World Patents Index; Class B03, AN 1996-055961, XP002181836
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