"Hydroalcoholic composition for the reduction of the viral activity" * * *

The present invention relates to a hydroalcoholic composition for the reduction of the viral activity through denaturation of membranes, protein material, cell lipids and viruses. In particular, the present invention relates to a hydroalcoholic composition, containing sterile water and ethanol or a physiological solution and ethanol, aimed at reducing viral activity, of the type applicable for internal or external use in order to limit the viral activity with particular reference to the Sars-Cov-2 virus, and to other viruses or viral pathogens.

The Sars-Cov-2, more generically and commonly referred to as coronavirus or by means of the name of the disease it causes, i.e., COVID 19, is an acellular micro-organism having parasitic characteristics, forced to replicate exclusively inside the cell of other organisms. The outer membrane of human cells is "soluble" in ethyl alcohol and in a mixture of water and ethyl alcohol (ethanol), or, as is known, ethyl alcohol and the mixture of water and ethyl alcohol (ethanol) denatures the protein material of the cells, attacking, together with the aforementioned protein material, the cells that host the parasite, causing the removal of the environmental and essential living conditions for said parasite. By pursuing the lysis, i.e., the destruction of the cells through the alteration and denaturation of their membrane, the decay of Sars-Cov-2, which has made the cells hosting it its "habitat, is in turn caused. In particular, the Sars-Cov-2 virus, when is present outside the cells and comes into contact with a mixture of water and ethyl alcohol, undergoes a disintegration process through the dissolution of the pericapsid made of a lipoprotein bilayer, inside which there is the protein coat consisting of Protein M or Matrix, that encloses the capsid nucleus with the genetic material (DNA or RNA; in the case of the Sars-Cov-2 the genetic material is RNA). If the virus is inside the infected host cells, an alcohol-water mixture, altering the membrane of the host cells, causes the exposure of the virus and its subsequent inactivation.

In other words, the Sars-Cov-2, and also other viruses, which have integrated and fused with the cells that host them, is destined to perish with said cells as a result of the decay of their membranes. The virus, unlike the cell, being a parasite, does not have a background that can allow it an autonomous life, nor the possibility of replicating itself, despite the genetic material it has (i.e., the RNA), while the cells, which have died due to the aggression carried out, to the detriment of their membrane, by the sterile distilled water - alcohol mixture, are replaced by others in line with the vital process.

The Sars-Cov-2 and other viruses, in this case, seek a protection in the cell membrane; in fact, as a good parasite, it is completed when it manages to penetrate the membrane, precisely because the ribonucleic acid (the RNA) of which it is made of, finds "completion", beyond the membrane, inside the human cell. But, as already mentioned, when the human cell membrane is destroyed by the mixture of sterile distilled water and alcohol, the Sars-Cov-2 virus, which due to the parasitic process is now part of the cell that hosts it and that takes on all of the vital characters of the aforementioned cell, dies following the destruction and the dissolution of the cell itself.

The Sars-Cov-2 virus, in this case, loses its vitality as a parasite, therefore, since it has been deprived of autonomous defenses and of those deriving from the cells in which it has infiltrated; the human cell in turn dies, but it is replaced, as already mentioned, by the renewal that characterizes all the cells of the organism that reproduce according to the vital process that characterizes them. The purpose of the present invention is to provide a hydroalcoholic composition, for internal or external use, for the reduction of the viral activity of viruses and, in particular, of the Sars-Cov-2 virus.

An hydroalcoholic composition according to the present invention is based on physiological solution and/or distilled water and ethanol in a concentration by volume comprised between 0.3 per thousand and 5 per thousand, for internal or external use for the reduction of the viral activity of at least one virus. According to an aspect of the invention, the hydroalcoholic composition is in liquid form and comprises ethanol in a concentration by volume comprised between 0.3 and 0.5 per thousand and physiological solution and/or distilled water for internal use in aerosol, spray, mechanical and forced ventilation or micronization of the hydroalcoholic composition in the treatment of viral infections .

According to an aspect of the invention, the hydroalcoholic composition according to the invention contains sterile distilled water and ethanol in a percentage comprised between 0.3 per thousand and 5 per thousand in volume and/or molar.

In particular, the concentration of ethanol in the hydroalcoholic composition for the reduction of the viral activity according to the invention is comprised between 0.3 per thousand and 0.5 per thousand by volume when the liquid composition is suitable for an internal use, for example in aerosols, sprays, mechanical and forced ventilation, or otherwise micronized.

According to another aspect of the invention, the concentration of ethanol in the composition according to the invention is comprised between 0.5 per thousand and 5 per thousand by volume when the composition is suitable for an external use, in the form of a gel or an ointment.

Advantageously, the Sars-Cov-2, like other viruses, may be attacked and probably inactivated directly and effectively in a short time on the skin, in the injured skin and mucous membranes and possibly in other systems, specifically the respiratory system, by using the hydroalcoholic composition according to the invention.

Such an effect occurs by virtue of the principle according to which the sterile distilled water - alcohol mixture according to the invention effectively denatures the proteins on the surface of viruses and bacteria and alters the lipid components of the membranes, thus allowing an inhibition of the microorganism. In the specific case of the Sars-Cov-2, the surface S proteins - spike- and the hypoproteic bilayer of the pericapsid are altered, so that the virus itself is inactivated.

Advantageously according to the invention, the hydroalcoholic composition for the reduction of the viral activity contains concentrations of ethanol that fall within the limits established in the highway code, not causing toxic effects or drunkenness.

Furthermore, the hydroalcoholic composition for the reduction of the viral activity according to the invention is effective and practical for internal or external use. It is finally clear that the hydroalcoholic composition for the reduction of the viral activity, described and illustrated herein, can be subject to modifications and variations without departing from the protective scope of the present invention, as defined in the appended claims.