HYDROCHLORIDE SALT OF CALCIUM-SENSING RECEPTOR AGONIST COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

HYDROCHLORIDE SALT OF CALCIUM-SENSING RECEPTOR AGONIST COMPOUND AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/257940

Kind Code:

A1

Abstract:

A hydrochloride salt of a calcium-sensing receptor agonist compound and a pharmaceutical composition and use thereof. Specifically, provided are a hydrochloride salt of a polypeptide calcium-sensing receptor agonist compound and a pharmaceutical composition and application thereof. The hydrochloride salt has an agonist effect on a human calcium-sensing receptor (CaSR) so as to reduce plasma parathyroid hormone and serum calcium ion level, and can be used for the treatment of metabolic diseases such as secondary hyperparathyroidism and tumor-induced hypercalcemia.

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Inventors:

HOU DALONG (CN)
KONG XIANGLIN (CN)
QI YANYAN (CN)
PENG ZHENG (CN)
GAO JUN (CN)
LIN FANCHENG (CN)

Application Number:

PCT/CN2022/097489

Publication Date:

December 15, 2022

Filing Date:

June 08, 2022

Export Citation:

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Assignee:

BEIJING TUO JIE BIOPHARMACEUTICAL CO LTD (CN)

International Classes:

C07K7/06; A61K38/08; A61P3/14; A61P5/18

Domestic Patent References:

WO2021115272A1	2021-06-17
WO2022052471A1	2022-03-17

Foreign References:

CN109985228A	2019-07-09
CN107674114A	2018-02-09

Attorney, Agent or Firm:

GE CHENG & CO., LTD (CN)

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