Title:
HYDROCHLORIDE SALT CRYSTAL OF DRUG FOR TREATING OR PREVENTING JAK-ASSOCIATED DISEASE AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/162139
Kind Code:
A1
Abstract:
Disclosed are a hydrochloride salt crystal of a drug (Filgotinib) for treating or preventing a JAK-associated disease and a preparation method, pharmaceutical composition, and formulation thereof, and an application of the hydrochloride salt crystal, the pharmaceutical composition, and the formulation in the prevention and/or treatment of a disease associated with a JAK family kinase. In comparison to a known crystal, the crystal provided in the invention shows more favorable properties in terms of pharmaceutical engineering, such as higher stability under low water activity conditions, simplicity in the preparation process and/or higher solubility.
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Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
LIU KAI (CN)
ZHANG XIAOYU (CN)
ZHANG YANFENG (CN)
LIU KAI (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2017/077492
Publication Date:
September 28, 2017
Filing Date:
March 21, 2017
Export Citation:
Assignee:
CRYSTAL PHARMATECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P19/02
Domestic Patent References:
WO2015117981A1 | 2015-08-13 | |||
WO2015117980A1 | 2015-08-13 | |||
WO2017012773A1 | 2017-01-26 | |||
WO2010149769A1 | 2010-12-29 | |||
WO2010149769A1 | 2010-12-29 | |||
WO2015011798A1 | 2015-01-29 | |||
WO2015117981A1 | 2015-08-13 |
Foreign References:
CN105669669A | 2016-06-15 |
Other References:
See also references of EP 3434675A4
Attorney, Agent or Firm:
BOSS&YOUNG PATENT AND TRADEMARK LAW OFFICE (CN)
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