Title:
HYDROGEL CAPSULE
Document Type and Number:
WIPO Patent Application WO/2019/182157
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide means for removing highly proliferative Ki67-positive cells that co-exist with differentiation-induced insulin-secreting cells. This method is for producing an insulin-producing cell population or a pancreatic beta cell population containing less than 3% of Ki67-positive cells, comprising embedding of an endocrine progenitor cell population or a cell population at a later differentiation stage in a gel containing alginic acid for further differentiation.
Inventors:
TOYODA TARO (JP)
MOCHIDA TAISUKE (JP)
TANOUE YUTAKA (JP)
ITO RYO (JP)
KIMOTO KOYA (JP)
KOIKE YUSUKE (JP)
UENO HIKARU (JP)
MOCHIDA TAISUKE (JP)
TANOUE YUTAKA (JP)
ITO RYO (JP)
KIMOTO KOYA (JP)
KOIKE YUSUKE (JP)
UENO HIKARU (JP)
Application Number:
PCT/JP2019/012289
Publication Date:
September 26, 2019
Filing Date:
March 18, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N5/16; A61K35/39; C12N11/04
Domestic Patent References:
| WO2010032242A1 | 2010-03-25 | |||
| WO2011154941A2 | 2011-12-15 | |||
| WO2009012428A2 | 2009-01-22 | |||
| WO2016021734A1 | 2016-02-11 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2008118220A2 | 2008-10-02 | |||
| WO2008124133A1 | 2008-10-16 | |||
| WO2008151058A2 | 2008-12-11 | |||
| WO2009006930A1 | 2009-01-15 | |||
| WO2009006997A1 | 2009-01-15 | |||
| WO2009007852A2 | 2009-01-15 | |||
| WO2010010902A1 | 2010-01-28 |
Foreign References:
| JP2005532259A | 2005-10-27 | |||
| JP2018051297A | 2018-04-05 | |||
| JP2008307007A | 2008-12-25 | |||
| JP2008283972A | 2008-11-27 | |||
| US20080233610A1 | 2008-09-25 | |||
| US20090047263A1 | 2009-02-19 |
Other References:
FORMO, K. ET AL.: "Culture of hESC-derived pancreatic progenitors in alginate-based scaffolds", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A, vol. 103, 4 June 2015 (2015-06-04), pages 3717 - 3726, XP055637761
RICHARDSON, T. ET AL.: "Alginate Encapsulation of Human Embryonic Stem Cells to Enhance Directed Differentiation to Pancreatic Islet-Like Cells", TISSUE ENGINEERING, vol. 20, 15 July 2014 (2014-07-15), pages 3198 - 3211, XP055637763
WEI, S. ET AL.: "Nanofibrous Microposts and Microwells of Controlled Shapes and Their Hybridization with Hydrogels for Cell Encapsulation", ACS APPLIED MATERIALS & INTERFACES, vol. 6, 7 May 2014 (2014-05-07), pages 7038 - 7044, XP055637764
VEGAS, A. J. ET AL.: "Long term glycemic control using polymer encapsulated, human stem- cell derived beta cells in immune competent mice", NATURE MEDICINE, vol. 22, no. 3, March 2016 (2016-03-01), pages 306 - 311, XP055563603, doi:10.1038/nm.4030
J BIOMED MATER RES A, vol. 103, no. 12, December 2015 (2015-12-01), pages 3717 - 26
TAKAHASHI KYAMANAKA S., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI KYAMANAKA S. ET AL., CELL, vol. 131, 2007, pages 861 - 872
OKITA, K.ICHISAKA, T.YAMANAKA, S., NATURE, vol. 451, 2007, pages 141 - 146
HUANGFU D.MELTON, DA. ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797
OKITA K ET AL., NAT. METHODS, vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
OKITA K ET AL., STEM CELLS, vol. 31, no. 3, pages 458 - 66
YU J.THOMSON JA. ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
SHI Y.DING S. ET AL., CELL STEM CELL, vol. 3, 2008, pages 568 - 574
KIM JB.SCHOLER HR. ET AL., NATURE, vol. 454, 2008, pages 646 - 650
TOYODA ET AL., STEM CELL RESEARCH, vol. 14, 2015, pages 185 - 197
NATURE BIOTECHNOLOGY, vol. 32, 2014, pages 1121 - 1133
See also references of EP 3770253A4
RICHARDSON, T. ET AL.: "Alginate Encapsulation of Human Embryonic Stem Cells to Enhance Directed Differentiation to Pancreatic Islet-Like Cells", TISSUE ENGINEERING, vol. 20, 15 July 2014 (2014-07-15), pages 3198 - 3211, XP055637763
WEI, S. ET AL.: "Nanofibrous Microposts and Microwells of Controlled Shapes and Their Hybridization with Hydrogels for Cell Encapsulation", ACS APPLIED MATERIALS & INTERFACES, vol. 6, 7 May 2014 (2014-05-07), pages 7038 - 7044, XP055637764
VEGAS, A. J. ET AL.: "Long term glycemic control using polymer encapsulated, human stem- cell derived beta cells in immune competent mice", NATURE MEDICINE, vol. 22, no. 3, March 2016 (2016-03-01), pages 306 - 311, XP055563603, doi:10.1038/nm.4030
J BIOMED MATER RES A, vol. 103, no. 12, December 2015 (2015-12-01), pages 3717 - 26
TAKAHASHI KYAMANAKA S., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI KYAMANAKA S. ET AL., CELL, vol. 131, 2007, pages 861 - 872
OKITA, K.ICHISAKA, T.YAMANAKA, S., NATURE, vol. 451, 2007, pages 141 - 146
HUANGFU D.MELTON, DA. ET AL., NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797
OKITA K ET AL., NAT. METHODS, vol. 8, no. 5, May 2011 (2011-05-01), pages 409 - 12
OKITA K ET AL., STEM CELLS, vol. 31, no. 3, pages 458 - 66
YU J.THOMSON JA. ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
SHI Y.DING S. ET AL., CELL STEM CELL, vol. 3, 2008, pages 568 - 574
KIM JB.SCHOLER HR. ET AL., NATURE, vol. 454, 2008, pages 646 - 650
TOYODA ET AL., STEM CELL RESEARCH, vol. 14, 2015, pages 185 - 197
NATURE BIOTECHNOLOGY, vol. 32, 2014, pages 1121 - 1133
See also references of EP 3770253A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
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