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Title:
HYDROGEL FOR DRUG RELEASE CONTROL AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/088541
Kind Code:
A1
Abstract:
The present invention provides a drug release means that is capable of independently controlling release of two or more kinds of drugs by supporting the drugs by a hydrogel which contains micelles of a cationic block polypeptide and micelles of an anionic block polypeptide, and wherein the micelles of a cationic block polypeptide or the micelles of an anionic block polypeptide are crosslinked by means of a crosslinking agent. This hydrogel is configured such that: the cationic block polypeptide is an amphiphilic cationic block polypeptide that contains a cationic amino acid side chain block and a hydrophobic amino acid side chain block; and the anionic block polypeptide is an amphiphilic anionic block polypeptide that contains an anionic amino acid side chain block and a hydrophobic amino acid side chain block.

Inventors:
MATSUMURA,Kazuaki (Japan Advanced Institute of Science and Technology 1, Asahidai 1-chome, Nomi-sh, Ishikawa 92, 〒9231292, JP)
PATEL,Monika (Japan Advanced Institute of Science and Technology 1, Asahidai 1-chome, Nomi-sh, Ishikawa 92, 〒9231292, JP)
Application Number:
JP2017/040648
Publication Date:
May 17, 2018
Filing Date:
November 10, 2017
Export Citation:
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Assignee:
JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (1 Asahidai 1-chome, Nomi-shi Ishikawa, 92, 〒9231292, JP)
International Classes:
A61K47/42; A61K9/06; A61K45/00; C07K2/00
Foreign References:
JP2006307004A2006-11-09
JP2010536554A2010-12-02
JP2015512938A2015-04-30
Other References:
NOWAK, A. P. ET AL.: "Hydrogel formation in amphiphilic triblock copolypeptides", SUPRAMOLECULAR CHEMISTRY, vol. 18, no. 5, 2006, pages 423 - 427, XP055484671, ISSN: 1029-0478
PAKSTIS, L. M. ET AL.: "Morphology of amphiphilic diblock polypeptides that controllably self-assemble into hydrogels and vesicles", 6TH INTERNATIONAL BIORELATED POLYMERS SYMPOSIUM, 2004, XP055503366
MATSUNAGA, JUN ET AL.: "Hyaluronic acid enabling multidrug sustained release control-Development of polymeric micelle composite gel", ABSTRACTS OF POLYMER PREPRINTS, vol. 63, no. 1, 2014, Japan, pages 3493
AKAGI, TAKAMI ET AL.: "Function of polyion complex nanoparticles composed of hydrophobically modified polyamino acids as a vaccine carrier", ABSTRACTS OF POLYMER PREPRINTS, vol. 60, no. 1, 2011, Japan, pages 1822
PATEL, M. ET AL.: "Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle-hydrogel composite", J. MATERIALS CHEMISTRY B, vol. 5, no. 19, 21 May 2017 (2017-05-21), pages 3488 - 3497, XP055484682, ISSN: 2050-750X
PATEL, M. ET AL.: "An amphiphilic polypeptide based shell linked micelle-hydrogel composite for dual drug release", THE 65TH MEETING OF HOKURIKU BRANCH OF THE POLYMER PREPRINTS, vol. 65, no. 65, 12 November 2016 (2016-11-12), Japan, pages 58
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL et al. (Shimbashi i-mark Bldg, 6-2 Shimbashi 2-Chome Minato-k, Tokyo 04, 〒1050004, JP)
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