Title:
HYDROGEL PARTICLE AND METHOD FOR PRODUCING SAME, CELL OR CELL STRUCTURE EACH ENCLOSING HYDROGEL PARTICLE THEREIN, METHOD FOR EVALUATING ACTIVITY OF CELL USING HYDROGEL PARTICLE, AND USE OF HYDROGEL PARTICLE AS SUSTAINED RELEASE PREPARATION
Document Type and Number:
WIPO Patent Application WO/2019/088292
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a hydrogel particle which can be taken into a cell by the action of the cell and can control the release of a magnetic particle enclosed therein into the cell so as to retain the magnetic particle in the cell for a long period; a method for producing the hydrogel particle; a cell or a cell structure each enclosing the hydrogel particle therein; and a method for evaluating the activity of a cell using the hydrogel particle. The present invention solves the problem by a hydrogel particle including: a domain which is composed of a first hydrogel; a matrix which encloses the domain and is composed of a second hydrogel having a different crosslinking degree or composition from that of the first hydrogel; and a magnetic particle which is supported by at least the first hydrogel.
Inventors:
TABATA YASUHIKO (JP)
MOCHIZUKI MAKOTO
INUI CHIE
HIRAYAMA NATSUMI
MAEZAWA AKIHIRO
MOCHIZUKI MAKOTO
INUI CHIE
HIRAYAMA NATSUMI
MAEZAWA AKIHIRO
Application Number:
PCT/JP2018/041035
Publication Date:
May 09, 2019
Filing Date:
November 05, 2018
Export Citation:
Assignee:
KONICA MINOLTA INC (JP)
TABATA YASUHIKO (JP)
TABATA YASUHIKO (JP)
International Classes:
C08J3/075; A61B5/055; A61K9/14; A61K47/42; A61K49/18; A61L27/38; A61L27/52; A61P43/00; B01J13/00; C08L101/14
Domestic Patent References:
| WO2017110746A1 | 2017-06-29 | |||
| WO2008016163A1 | 2008-02-07 | |||
| WO2007111232A1 | 2007-10-04 |
Foreign References:
| JP2008150596A | 2008-07-03 | |||
| JP2011207887A | 2011-10-20 | |||
| JP2001267112A | 2001-09-28 | |||
| JP2006273740A | 2006-10-12 | |||
| JP2008214324A | 2008-09-18 | |||
| JP2010208979A | 2010-09-24 | |||
| JP2017213707A | 2017-12-07 |
Other References:
TOMITAKA, A. ET AL.: "Preparation of biodegradable iron oxide nanoparticles with gelatin for magnetic resonance imaging", INFLAMMATION AND REGENERATION, vol. 34, no. l, 2014, pages 45 - 55
PROF. OKANO, NATURE MEDICINE, vol. 13, 1 July 2007 (2007-07-01), pages 880 - 885
See also references of EP 3708605A4
PROF. OKANO, NATURE MEDICINE, vol. 13, 1 July 2007 (2007-07-01), pages 880 - 885
See also references of EP 3708605A4
Attorney, Agent or Firm:
WASHIDA, Kimihito (JP)
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