HYDROGEL USING, AS SUBSTRATE, HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AND USE THEREOF

WIPO Patent Application WO/2018/143736

A1

The present invention provides a hydrogel platform using, as a substrate, hyaluronic acid (HA) conjugated to a pyrogallol (PG) moiety. The HA-PG conjugate of the present invention can be promptly crosslinked by two different methods, such as using an oxidant or adjusting pH. The hydrogel of the present invention can efficiently control physical characteristics, such as a crosslinking rate, elasticity, and adhesive strength, according to the crosslinking manner of each, while having excellent biocompatibility. The hydrogel of the present invention can be used, on the basis of such excellent stability and functionality thereof, in various fields including drug delivery, biopharmaceutical materials such as a wound healing agent or anti-adhesive agent, medicines, and cosmetic products.

CHO SEUNG WOO (KR)
LEE JUNG-SEUNG (KR)
CHO JUNG HO (KR)
LEE JONG-SEUNG (KR)

PCT/KR2018/001473

August 09, 2018

February 02, 2018

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AMTIXBIO CO LTD (KR)

C08B37/08; A61K47/36; A61L27/20; A61L27/54; C08J3/075; C08L5/08

WO2015174934A1

2015-11-19

KR20090013696A	2009-02-05
KR20070076386A	2007-07-24
KR20160072592A	2016-06-23
KR20140072008A	2014-06-12
US4582865A	1986-04-15
US4713448A	1987-12-15
US5356883A	1994-10-18

SHIN, M. ET AL.: "Gallol-Rich Hyaluronic Acid Hydrogels: Shear-Thinning, Protein Accumulation against Concentration Gradients, and Degradation Resistant Properties", CHEMISTRY OF MATERIALS, vol. 29, 21 September 2017 (2017-09-21), pages 8211 - 8220, XP055532231
See also references of EP 3578573A4

LEE, Jong-Seung (KR)

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